Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine

Background The replacement of β,γ-pyrophosphate by β,γ-phosphonate moieties within the triphosphate chain of 5′-triphosphate nucleoside analogues was previously studied for various antiviral nucleoside analogues such as AZT and 2′,3′-dideoxynucleosides. Thus, it has been shown that these chemical mo...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 2018-01, Vol.26, p.2040206618757636-2040206618757636
Hauptverfasser:	Laux, Wolfgang HG, Priet, Stéphane, Alvarez, Karine, Peyrottes, Suzanne, Périgaud, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adefovir Adenine Biochemistry Biochemistry, Molecular Biology HIV Human immunodeficiency virus Life Sciences Nucleoside analogs Nucleotide analogs Original Phosphonates Phosphorus RNA-directed DNA polymerase Zidovudine
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