Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

Repurposing metformin for cancer therapy is attractive due to its safety profile, epidemiological evidence, and encouraging data from human clinical trials. Although it is known to systemically affect glucose metabolism in liver, muscle, gut, and other tissues, the molecular determinants that predic...

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Veröffentlicht in:	Cell metabolism 2016-11, Vol.24 (5), p.728-739
Hauptverfasser:	Liu, Xiaojing, Romero, Iris L., Litchfield, Lacey M., Lengyel, Ernst, Locasale, Jason W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon - metabolism Cell Line, Tumor cell proliferation Dose-Response Relationship, Drug Female flux analysis Glucose - pharmacology Humans mass spectrometry Metabolome - drug effects metabolomics Metformin - pharmacology Mice mitochondria Mitochondria - drug effects Mitochondria - metabolism network analysis ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Substrate Specificity - drug effects systems biology Treatment Outcome
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