Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress

Background. Renal fibrosis is a common pathological symptom of chronic kidney disease (CKD). Many studies support that mitochondrial dysfunction and endoplasmic reticulum (ER) stress are implicated in the pathogenesis of CKD. In our study, we investigated the benefits and underlying mechanisms of Mi...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-13
Hauptverfasser:	Wang, Yingdeng, Ding, Wei, Wang, Yundan, Liu, Yuqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biosynthesis Biotechnology Chronic kidney failure Cyclic N-Oxides - pharmacology Cyclic N-Oxides - therapeutic use Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Fibrosis Fibrosis - drug therapy Fibrosis - pathology Immunoglobulins Immunohistochemistry Inflammation Inflammation - drug therapy Kidney diseases Kidney Diseases - drug therapy Kidney Diseases - pathology Laboratory animals Male Medical research Medicine, Experimental Mice Mitochondria Mitochondria - metabolism Mitochondrial DNA Oxidative stress Physiology Proteins Rodents Superoxide
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