Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

A subset of patients with non-alcoholic fatty liver disease develop an inflammatory condition, termed non-alcoholic steatohepatitis (NASH). NASH is characterised by hepatocellular injury, innate immune cell-mediated inflammation and progressive liver fibrosis. The mechanisms whereby hepatic inflamma...

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Veröffentlicht in:	Gut 2018-05, Vol.67 (5), p.963-972
Hauptverfasser:	Ibrahim, Samar H, Hirsova, Petra, Gores, Gregory J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Fatty acids Fatty liver Fibrosis Hepatology Inflammation Insulin resistance Ligands Lipids Liver diseases Pathogenesis Rodents Signal transduction
Online-Zugang:	Volltext
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