Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases
Gram-negative bacterium-released outer-membrane vesicles (OMVs) and Gram-positive bacterium-released membrane vesicles (MVs) share significant similarities with mammalian cell-derived MVs ( eg , microvesicles and exosomes) in terms of structure and their biological activities. Recent studies have re...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2018-04, Vol.39 (4), p.514-533 |
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| creator | Yu, You-jiang Wang, Xiao-hong Fan, Guo-Chang |
| description | Gram-negative bacterium-released outer-membrane vesicles (OMVs) and Gram-positive bacterium-released membrane vesicles (MVs) share significant similarities with mammalian cell-derived MVs (
eg
, microvesicles and exosomes) in terms of structure and their biological activities. Recent studies have revealed that bacterial OMVs/MVs could (1) interact with immune cells to regulate inflammatory responses, (2) transport virulence factors (
eg
, enzymes, DNA and small RNAs) to host cells and result in cell injury, (3) enhance barrier function by stimulating the expression of tight junction proteins in intestinal epithelial cells, (4) upregulate the expression of endothelial cell adhesion molecules, and (5) serve as natural nanocarriers for immunogenic antigens, enzyme support and drug delivery. In addition, OMVs/MVs can enter the systemic circulation and induce a variety of immunological and metabolic responses. This review highlights the recent advances in the understanding of OMV/MV biogenesis and their compositional remodeling. In addition, interactions between OMVs/MVs and various types of mammalian cells (
ie
, immune cells, epithelial cells, and endothelial cells) and their pathological/preventive effects on infectious/inflammatory diseases are summarized. Finally, methods for engineering OMVs/MVs and their therapeutic potential are discussed. |
| doi_str_mv | 10.1038/aps.2017.82 |
| format | Article |
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eg
, microvesicles and exosomes) in terms of structure and their biological activities. Recent studies have revealed that bacterial OMVs/MVs could (1) interact with immune cells to regulate inflammatory responses, (2) transport virulence factors (
eg
, enzymes, DNA and small RNAs) to host cells and result in cell injury, (3) enhance barrier function by stimulating the expression of tight junction proteins in intestinal epithelial cells, (4) upregulate the expression of endothelial cell adhesion molecules, and (5) serve as natural nanocarriers for immunogenic antigens, enzyme support and drug delivery. In addition, OMVs/MVs can enter the systemic circulation and induce a variety of immunological and metabolic responses. This review highlights the recent advances in the understanding of OMV/MV biogenesis and their compositional remodeling. In addition, interactions between OMVs/MVs and various types of mammalian cells (
ie
, immune cells, epithelial cells, and endothelial cells) and their pathological/preventive effects on infectious/inflammatory diseases are summarized. Finally, methods for engineering OMVs/MVs and their therapeutic potential are discussed.</description><identifier>ISSN: 1671-4083</identifier><identifier>ISSN: 1745-7254</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/aps.2017.82</identifier><identifier>PMID: 28858295</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Antigens ; Bacteria - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cell adhesion ; Cell adhesion & migration ; Cell adhesion molecules ; Cell injury ; Communicable Diseases - physiopathology ; Communicable Diseases - therapy ; Dendritic Cells - metabolism ; Deoxyribonucleic acid ; DNA ; Drug delivery ; Endothelial cells ; Epithelial cells ; Exosomes ; Extracellular Vesicles - chemistry ; Extracellular Vesicles - immunology ; Extracellular Vesicles - metabolism ; Extracellular Vesicles - microbiology ; Humans ; Immunogenicity ; Immunology ; Inflammation - physiopathology ; Inflammatory diseases ; Internal Medicine ; Intestine ; Mammalian cells ; Medical Microbiology ; Membrane vesicles ; Phagocytes - metabolism ; Pharmacology/Toxicology ; Proteins ; Review ; review-article ; Vaccine ; Vaccines, Acellular - therapeutic use ; Vesicles ; Virulence factors</subject><ispartof>Acta pharmacologica Sinica, 2018-04, Vol.39 (4), p.514-533</ispartof><rights>CPS and SIMM 2018</rights><rights>Copyright Nature Publishing Group Apr 2018</rights><rights>Copyright © 2018 CPS and SIMM 2018 CPS and SIMM</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-8cdcd138e8a70ed53b3e6d8bf0a12ffdaa26993e62bc7b6cbf79f1e6a97950f13</citedby><cites>FETCH-LOGICAL-c512t-8cdcd138e8a70ed53b3e6d8bf0a12ffdaa26993e62bc7b6cbf79f1e6a97950f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888691/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888691/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28858295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, You-jiang</creatorcontrib><creatorcontrib>Wang, Xiao-hong</creatorcontrib><creatorcontrib>Fan, Guo-Chang</creatorcontrib><title>Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacol Sin</addtitle><description>Gram-negative bacterium-released outer-membrane vesicles (OMVs) and Gram-positive bacterium-released membrane vesicles (MVs) share significant similarities with mammalian cell-derived MVs (
eg
, microvesicles and exosomes) in terms of structure and their biological activities. Recent studies have revealed that bacterial OMVs/MVs could (1) interact with immune cells to regulate inflammatory responses, (2) transport virulence factors (
eg
, enzymes, DNA and small RNAs) to host cells and result in cell injury, (3) enhance barrier function by stimulating the expression of tight junction proteins in intestinal epithelial cells, (4) upregulate the expression of endothelial cell adhesion molecules, and (5) serve as natural nanocarriers for immunogenic antigens, enzyme support and drug delivery. In addition, OMVs/MVs can enter the systemic circulation and induce a variety of immunological and metabolic responses. This review highlights the recent advances in the understanding of OMV/MV biogenesis and their compositional remodeling. In addition, interactions between OMVs/MVs and various types of mammalian cells (
ie
, immune cells, epithelial cells, and endothelial cells) and their pathological/preventive effects on infectious/inflammatory diseases are summarized. Finally, methods for engineering OMVs/MVs and their therapeutic potential are discussed.</description><subject>Animals</subject><subject>Antigens</subject><subject>Bacteria - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell adhesion molecules</subject><subject>Cell injury</subject><subject>Communicable Diseases - physiopathology</subject><subject>Communicable Diseases - therapy</subject><subject>Dendritic Cells - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug delivery</subject><subject>Endothelial cells</subject><subject>Epithelial cells</subject><subject>Exosomes</subject><subject>Extracellular Vesicles - chemistry</subject><subject>Extracellular Vesicles - immunology</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Extracellular Vesicles - microbiology</subject><subject>Humans</subject><subject>Immunogenicity</subject><subject>Immunology</subject><subject>Inflammation - physiopathology</subject><subject>Inflammatory diseases</subject><subject>Internal Medicine</subject><subject>Intestine</subject><subject>Mammalian cells</subject><subject>Medical Microbiology</subject><subject>Membrane vesicles</subject><subject>Phagocytes - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Proteins</subject><subject>Review</subject><subject>review-article</subject><subject>Vaccine</subject><subject>Vaccines, Acellular - therapeutic use</subject><subject>Vesicles</subject><subject>Virulence factors</subject><issn>1671-4083</issn><issn>1745-7254</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkctrFTEUhwdR7ENX7iXgRtC5zWMySTaCFKtCwY26DZnkpKYkmdtkptD_3gy31geucsj5-HJOfl33guAdwUyemX3dUUzETtJH3TERA-8F5cPjVo-C9AOW7Kg7qfUaY0YZUU-7Iyoll1Tx4-7mO5RqlhABgfdgl4pmjyZjFyhhTX2BCKaCQwnSVEwGdAs12AiNyyiZlEwMJiMLMVZkskMhb5owr_WslXEjlrncIRfqZqrPuifexArP78_T7tvFh6_nn_rLLx8_n7-_7C0ndOmlddYRJkEagcFxNjEYnZw8NoR674yho1Ltjk5WTKOdvFCewGiUUBx7wk67dwfvfp0SOAt5KSbqfQnJlDs9m6D_7uTwQ1_Nt5pLKUe1CV7fC8p8s0JddAp127P9QttOE8UGKhmnQ0Nf_YNez2vJbT1NMcWDGKnCjXpzoGyZay3gH4YhWG9R6hal3qLUkjb65Z_zP7C_smvA2wNQWytfQfn96P98PwGR86zR</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Yu, You-jiang</creator><creator>Wang, Xiao-hong</creator><creator>Fan, Guo-Chang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases</title><author>Yu, You-jiang ; Wang, Xiao-hong ; Fan, Guo-Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-8cdcd138e8a70ed53b3e6d8bf0a12ffdaa26993e62bc7b6cbf79f1e6a97950f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Bacteria - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell adhesion molecules</topic><topic>Cell injury</topic><topic>Communicable Diseases - physiopathology</topic><topic>Communicable Diseases - therapy</topic><topic>Dendritic Cells - metabolism</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug delivery</topic><topic>Endothelial cells</topic><topic>Epithelial cells</topic><topic>Exosomes</topic><topic>Extracellular Vesicles - chemistry</topic><topic>Extracellular Vesicles - immunology</topic><topic>Extracellular Vesicles - metabolism</topic><topic>Extracellular Vesicles - microbiology</topic><topic>Humans</topic><topic>Immunogenicity</topic><topic>Immunology</topic><topic>Inflammation - physiopathology</topic><topic>Inflammatory diseases</topic><topic>Internal Medicine</topic><topic>Intestine</topic><topic>Mammalian cells</topic><topic>Medical Microbiology</topic><topic>Membrane vesicles</topic><topic>Phagocytes - metabolism</topic><topic>Pharmacology/Toxicology</topic><topic>Proteins</topic><topic>Review</topic><topic>review-article</topic><topic>Vaccine</topic><topic>Vaccines, Acellular - therapeutic use</topic><topic>Vesicles</topic><topic>Virulence factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, You-jiang</creatorcontrib><creatorcontrib>Wang, Xiao-hong</creatorcontrib><creatorcontrib>Fan, Guo-Chang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, You-jiang</au><au>Wang, Xiao-hong</au><au>Fan, Guo-Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases</atitle><jtitle>Acta pharmacologica Sinica</jtitle><stitle>Acta Pharmacol Sin</stitle><addtitle>Acta Pharmacol Sin</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>39</volume><issue>4</issue><spage>514</spage><epage>533</epage><pages>514-533</pages><issn>1671-4083</issn><issn>1745-7254</issn><eissn>1745-7254</eissn><abstract>Gram-negative bacterium-released outer-membrane vesicles (OMVs) and Gram-positive bacterium-released membrane vesicles (MVs) share significant similarities with mammalian cell-derived MVs (
eg
, microvesicles and exosomes) in terms of structure and their biological activities. Recent studies have revealed that bacterial OMVs/MVs could (1) interact with immune cells to regulate inflammatory responses, (2) transport virulence factors (
eg
, enzymes, DNA and small RNAs) to host cells and result in cell injury, (3) enhance barrier function by stimulating the expression of tight junction proteins in intestinal epithelial cells, (4) upregulate the expression of endothelial cell adhesion molecules, and (5) serve as natural nanocarriers for immunogenic antigens, enzyme support and drug delivery. In addition, OMVs/MVs can enter the systemic circulation and induce a variety of immunological and metabolic responses. This review highlights the recent advances in the understanding of OMV/MV biogenesis and their compositional remodeling. In addition, interactions between OMVs/MVs and various types of mammalian cells (
ie
, immune cells, epithelial cells, and endothelial cells) and their pathological/preventive effects on infectious/inflammatory diseases are summarized. Finally, methods for engineering OMVs/MVs and their therapeutic potential are discussed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28858295</pmid><doi>10.1038/aps.2017.82</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigens Bacteria - metabolism Biomedical and Life Sciences Biomedicine Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell injury Communicable Diseases - physiopathology Communicable Diseases - therapy Dendritic Cells - metabolism Deoxyribonucleic acid DNA Drug delivery Endothelial cells Epithelial cells Exosomes Extracellular Vesicles - chemistry Extracellular Vesicles - immunology Extracellular Vesicles - metabolism Extracellular Vesicles - microbiology Humans Immunogenicity Immunology Inflammation - physiopathology Inflammatory diseases Internal Medicine Intestine Mammalian cells Medical Microbiology Membrane vesicles Phagocytes - metabolism Pharmacology/Toxicology Proteins Review review-article Vaccine Vaccines, Acellular - therapeutic use Vesicles Virulence factors |
| title | Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases |
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