Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148

Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like protein tyrosine-phosphatase CD148 in mice results in a dramatic increase i...

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Veröffentlicht in:	Blood 2018-03, Vol.131 (10), p.1122-1144
Hauptverfasser:	Mori, Jun, Nagy, Zoltan, Di Nunzio, Giada, Smith, Christopher W., Geer, Mitchell J., Al Ghaithi, Rashid, van Geffen, Johanna P., Heising, Silke, Boothman, Luke, Tullemans, Bibian M.E., Correia, Joao N., Tee, Louise, Kuijpers, Marijke J.E., Harrison, Paul, Heemskerk, Johan W.M., Jarvis, Gavin E., Tarakhovsky, Alexander, Weiss, Arthur, Mazharian, Alexandra, Senis, Yotis A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Blood Platelets - metabolism Blood Platelets - pathology CSK Tyrosine-Protein Kinase Homeostasis Mice Mice, Knockout Platelet Membrane Glycoproteins - genetics Platelet Membrane Glycoproteins - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism src-Family Kinases - genetics src-Family Kinases - metabolism Thrombosis - genetics Thrombosis - metabolism Thrombosis and Hemostasis
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