S26. HERITABILITY OF SOCIAL MISTRUST IN CHILD AND ADOLESCENT NON-CLINICAL SAMPLES: A HEALTHY TWINS STUDY

Abstract Background Paranoia, or excessive suspiciousness of others, has been one of the core psychotic symptoms of schizophrenia. Recent studies have extended the study of psychotic symptoms in clinical groups to psychotic-like experiences in the general population. Few studies have systematically...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Schizophrenia bulletin 2018-04, Vol.44 (suppl_1), p.S333-S333
Hauptverfasser: Zhou, Han-yu, Wong, Keri, Shi, Li-juan, Cui, Xi-long, Qian, Yun, Du, Ya-song, Lui, Simon S Y, Luo, Xue-rong, Cheung, Eric F C, Docherty, Anna, Chan, Raymond
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page S333
container_issue suppl_1
container_start_page S333
container_title Schizophrenia bulletin
container_volume 44
creator Zhou, Han-yu
Wong, Keri
Shi, Li-juan
Cui, Xi-long
Qian, Yun
Du, Ya-song
Lui, Simon S Y
Luo, Xue-rong
Cheung, Eric F C
Docherty, Anna
Chan, Raymond
description Abstract Background Paranoia, or excessive suspiciousness of others, has been one of the core psychotic symptoms of schizophrenia. Recent studies have extended the study of psychotic symptoms in clinical groups to psychotic-like experiences in the general population. Few studies have systematically examined the prevalence of paranoid thinking or its attenuated form, social mistrust, in young children in the community. The present study examined the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. Methods We administered the SMS to 1047 pairs of healthy twins aged 8 to 14 years and conducted structural equation modelling (SEM) to assess the structure of the SMS. Heritability of social mistrust was estimated in a sub-sample of twins (n=959 pairs). Finally, we examined administered the SMS to 32 adolescents with childhood-onset schizophrenia and 34 healthy controls to examine the convergent validity between the SMS and the Positive and Negative Syndrome Scale (PANSS). Results The SEM showed a three-factor structure for social mistrust (home, school, and general mistrust). Social mistrust was moderately heritable (39%, 95% CI [21%-59%]) with context-dependent sex differences. The SMS exhibited good discriminant validity in distinguishing adolescents with childhood-onset schizophrenia from healthy controls (AUC=0.80), and good convergent validity with the Positive and Negative Syndrome Scale (rs = 0.33–0.45). Discussion Taken together, the present findings showed a stable latent structure of the SMS in a large-scale non-clinical sample of children and adolescents. We found a moderate heritability estimate for social mistrust (39%) in a large healthy-twin sample. In addition, significant gender differences were found, where home mistrust was heritable for males (58%) but not for females, and school mistrust was heritable for females (54%) but not for males. Finally, we also demonstrated that the SMS possesses good discriminate validity in identifying adolescents with childhood-onset schizophrenia from healthy controls and convergent validity with standardized clinical measures of schizophrenia symptoms.
doi_str_mv 10.1093/schbul/sby018.813
format Article
fullrecord <record><control><sourceid>oup_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5887797</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/schbul/sby018.813</oup_id><sourcerecordid>10.1093/schbul/sby018.813</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1773-df88e8883b070667d8adcafea645075f17ffb3f1c44d831686ca35afca96708e3</originalsourceid><addsrcrecordid>eNqNkEFLwzAYhoMoOKc_wFt-gN2StU1SD0LtOhvoWlkyZKeQpo2bbOtonbB_b0dF8Obh4zu87_scHgDuMRphFLjj1qyL43bcFieE2Yhh9wIMMPV8B1OEL8EA-Yw4lGDvGty07QdC2AvIZADWYkJGMIkXXIbPPOVyBfMZFHnEwxTOuZCLpZCQZzBKeDqFYdbdNE9jEcWZhFmeOVHKMx51bRHOX7vgEYYdL0xlsoLyjWcCCrmcrm7BldXbtrr7-UOwnMUySpw0fznPHYMpdZ3SMlYxxtwCUUQILZkujbaVJp6PqG8xtbZwLTaeVzIXE0aMdn1tjQ4IRaxyh-Cp5x6Oxa4qTbX_bPRWHZrNTjcnVeuN-pvsN2v1Xn8pnzFKA9oBcA8wTd22TWV_txips2vVu1a9a9W57jYP_aY-Hv5R_wbFPXzG</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>S26. HERITABILITY OF SOCIAL MISTRUST IN CHILD AND ADOLESCENT NON-CLINICAL SAMPLES: A HEALTHY TWINS STUDY</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhou, Han-yu ; Wong, Keri ; Shi, Li-juan ; Cui, Xi-long ; Qian, Yun ; Du, Ya-song ; Lui, Simon S Y ; Luo, Xue-rong ; Cheung, Eric F C ; Docherty, Anna ; Chan, Raymond</creator><creatorcontrib>Zhou, Han-yu ; Wong, Keri ; Shi, Li-juan ; Cui, Xi-long ; Qian, Yun ; Du, Ya-song ; Lui, Simon S Y ; Luo, Xue-rong ; Cheung, Eric F C ; Docherty, Anna ; Chan, Raymond</creatorcontrib><description>Abstract Background Paranoia, or excessive suspiciousness of others, has been one of the core psychotic symptoms of schizophrenia. Recent studies have extended the study of psychotic symptoms in clinical groups to psychotic-like experiences in the general population. Few studies have systematically examined the prevalence of paranoid thinking or its attenuated form, social mistrust, in young children in the community. The present study examined the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. Methods We administered the SMS to 1047 pairs of healthy twins aged 8 to 14 years and conducted structural equation modelling (SEM) to assess the structure of the SMS. Heritability of social mistrust was estimated in a sub-sample of twins (n=959 pairs). Finally, we examined administered the SMS to 32 adolescents with childhood-onset schizophrenia and 34 healthy controls to examine the convergent validity between the SMS and the Positive and Negative Syndrome Scale (PANSS). Results The SEM showed a three-factor structure for social mistrust (home, school, and general mistrust). Social mistrust was moderately heritable (39%, 95% CI [21%-59%]) with context-dependent sex differences. The SMS exhibited good discriminant validity in distinguishing adolescents with childhood-onset schizophrenia from healthy controls (AUC=0.80), and good convergent validity with the Positive and Negative Syndrome Scale (rs = 0.33–0.45). Discussion Taken together, the present findings showed a stable latent structure of the SMS in a large-scale non-clinical sample of children and adolescents. We found a moderate heritability estimate for social mistrust (39%) in a large healthy-twin sample. In addition, significant gender differences were found, where home mistrust was heritable for males (58%) but not for females, and school mistrust was heritable for females (54%) but not for males. Finally, we also demonstrated that the SMS possesses good discriminate validity in identifying adolescents with childhood-onset schizophrenia from healthy controls and convergent validity with standardized clinical measures of schizophrenia symptoms.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/schbul/sby018.813</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Abstracts</subject><ispartof>Schizophrenia bulletin, 2018-04, Vol.44 (suppl_1), p.S333-S333</ispartof><rights>Maryland Psychiatric Research Center 2018. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887797/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887797/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1584,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Zhou, Han-yu</creatorcontrib><creatorcontrib>Wong, Keri</creatorcontrib><creatorcontrib>Shi, Li-juan</creatorcontrib><creatorcontrib>Cui, Xi-long</creatorcontrib><creatorcontrib>Qian, Yun</creatorcontrib><creatorcontrib>Du, Ya-song</creatorcontrib><creatorcontrib>Lui, Simon S Y</creatorcontrib><creatorcontrib>Luo, Xue-rong</creatorcontrib><creatorcontrib>Cheung, Eric F C</creatorcontrib><creatorcontrib>Docherty, Anna</creatorcontrib><creatorcontrib>Chan, Raymond</creatorcontrib><title>S26. HERITABILITY OF SOCIAL MISTRUST IN CHILD AND ADOLESCENT NON-CLINICAL SAMPLES: A HEALTHY TWINS STUDY</title><title>Schizophrenia bulletin</title><description>Abstract Background Paranoia, or excessive suspiciousness of others, has been one of the core psychotic symptoms of schizophrenia. Recent studies have extended the study of psychotic symptoms in clinical groups to psychotic-like experiences in the general population. Few studies have systematically examined the prevalence of paranoid thinking or its attenuated form, social mistrust, in young children in the community. The present study examined the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. Methods We administered the SMS to 1047 pairs of healthy twins aged 8 to 14 years and conducted structural equation modelling (SEM) to assess the structure of the SMS. Heritability of social mistrust was estimated in a sub-sample of twins (n=959 pairs). Finally, we examined administered the SMS to 32 adolescents with childhood-onset schizophrenia and 34 healthy controls to examine the convergent validity between the SMS and the Positive and Negative Syndrome Scale (PANSS). Results The SEM showed a three-factor structure for social mistrust (home, school, and general mistrust). Social mistrust was moderately heritable (39%, 95% CI [21%-59%]) with context-dependent sex differences. The SMS exhibited good discriminant validity in distinguishing adolescents with childhood-onset schizophrenia from healthy controls (AUC=0.80), and good convergent validity with the Positive and Negative Syndrome Scale (rs = 0.33–0.45). Discussion Taken together, the present findings showed a stable latent structure of the SMS in a large-scale non-clinical sample of children and adolescents. We found a moderate heritability estimate for social mistrust (39%) in a large healthy-twin sample. In addition, significant gender differences were found, where home mistrust was heritable for males (58%) but not for females, and school mistrust was heritable for females (54%) but not for males. Finally, we also demonstrated that the SMS possesses good discriminate validity in identifying adolescents with childhood-onset schizophrenia from healthy controls and convergent validity with standardized clinical measures of schizophrenia symptoms.</description><subject>Abstracts</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqNkEFLwzAYhoMoOKc_wFt-gN2StU1SD0LtOhvoWlkyZKeQpo2bbOtonbB_b0dF8Obh4zu87_scHgDuMRphFLjj1qyL43bcFieE2Yhh9wIMMPV8B1OEL8EA-Yw4lGDvGty07QdC2AvIZADWYkJGMIkXXIbPPOVyBfMZFHnEwxTOuZCLpZCQZzBKeDqFYdbdNE9jEcWZhFmeOVHKMx51bRHOX7vgEYYdL0xlsoLyjWcCCrmcrm7BldXbtrr7-UOwnMUySpw0fznPHYMpdZ3SMlYxxtwCUUQILZkujbaVJp6PqG8xtbZwLTaeVzIXE0aMdn1tjQ4IRaxyh-Cp5x6Oxa4qTbX_bPRWHZrNTjcnVeuN-pvsN2v1Xn8pnzFKA9oBcA8wTd22TWV_txips2vVu1a9a9W57jYP_aY-Hv5R_wbFPXzG</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Zhou, Han-yu</creator><creator>Wong, Keri</creator><creator>Shi, Li-juan</creator><creator>Cui, Xi-long</creator><creator>Qian, Yun</creator><creator>Du, Ya-song</creator><creator>Lui, Simon S Y</creator><creator>Luo, Xue-rong</creator><creator>Cheung, Eric F C</creator><creator>Docherty, Anna</creator><creator>Chan, Raymond</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>S26. HERITABILITY OF SOCIAL MISTRUST IN CHILD AND ADOLESCENT NON-CLINICAL SAMPLES: A HEALTHY TWINS STUDY</title><author>Zhou, Han-yu ; Wong, Keri ; Shi, Li-juan ; Cui, Xi-long ; Qian, Yun ; Du, Ya-song ; Lui, Simon S Y ; Luo, Xue-rong ; Cheung, Eric F C ; Docherty, Anna ; Chan, Raymond</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1773-df88e8883b070667d8adcafea645075f17ffb3f1c44d831686ca35afca96708e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abstracts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Han-yu</creatorcontrib><creatorcontrib>Wong, Keri</creatorcontrib><creatorcontrib>Shi, Li-juan</creatorcontrib><creatorcontrib>Cui, Xi-long</creatorcontrib><creatorcontrib>Qian, Yun</creatorcontrib><creatorcontrib>Du, Ya-song</creatorcontrib><creatorcontrib>Lui, Simon S Y</creatorcontrib><creatorcontrib>Luo, Xue-rong</creatorcontrib><creatorcontrib>Cheung, Eric F C</creatorcontrib><creatorcontrib>Docherty, Anna</creatorcontrib><creatorcontrib>Chan, Raymond</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Han-yu</au><au>Wong, Keri</au><au>Shi, Li-juan</au><au>Cui, Xi-long</au><au>Qian, Yun</au><au>Du, Ya-song</au><au>Lui, Simon S Y</au><au>Luo, Xue-rong</au><au>Cheung, Eric F C</au><au>Docherty, Anna</au><au>Chan, Raymond</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>S26. HERITABILITY OF SOCIAL MISTRUST IN CHILD AND ADOLESCENT NON-CLINICAL SAMPLES: A HEALTHY TWINS STUDY</atitle><jtitle>Schizophrenia bulletin</jtitle><date>2018-04-01</date><risdate>2018</risdate><volume>44</volume><issue>suppl_1</issue><spage>S333</spage><epage>S333</epage><pages>S333-S333</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><abstract>Abstract Background Paranoia, or excessive suspiciousness of others, has been one of the core psychotic symptoms of schizophrenia. Recent studies have extended the study of psychotic symptoms in clinical groups to psychotic-like experiences in the general population. Few studies have systematically examined the prevalence of paranoid thinking or its attenuated form, social mistrust, in young children in the community. The present study examined the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. Methods We administered the SMS to 1047 pairs of healthy twins aged 8 to 14 years and conducted structural equation modelling (SEM) to assess the structure of the SMS. Heritability of social mistrust was estimated in a sub-sample of twins (n=959 pairs). Finally, we examined administered the SMS to 32 adolescents with childhood-onset schizophrenia and 34 healthy controls to examine the convergent validity between the SMS and the Positive and Negative Syndrome Scale (PANSS). Results The SEM showed a three-factor structure for social mistrust (home, school, and general mistrust). Social mistrust was moderately heritable (39%, 95% CI [21%-59%]) with context-dependent sex differences. The SMS exhibited good discriminant validity in distinguishing adolescents with childhood-onset schizophrenia from healthy controls (AUC=0.80), and good convergent validity with the Positive and Negative Syndrome Scale (rs = 0.33–0.45). Discussion Taken together, the present findings showed a stable latent structure of the SMS in a large-scale non-clinical sample of children and adolescents. We found a moderate heritability estimate for social mistrust (39%) in a large healthy-twin sample. In addition, significant gender differences were found, where home mistrust was heritable for males (58%) but not for females, and school mistrust was heritable for females (54%) but not for males. Finally, we also demonstrated that the SMS possesses good discriminate validity in identifying adolescents with childhood-onset schizophrenia from healthy controls and convergent validity with standardized clinical measures of schizophrenia symptoms.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/schbul/sby018.813</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0586-7614
ispartof Schizophrenia bulletin, 2018-04, Vol.44 (suppl_1), p.S333-S333
issn 0586-7614
1745-1701
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5887797
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); PubMed Central; Alma/SFX Local Collection
subjects Abstracts
title S26. HERITABILITY OF SOCIAL MISTRUST IN CHILD AND ADOLESCENT NON-CLINICAL SAMPLES: A HEALTHY TWINS STUDY
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T10%3A31%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=S26.%20HERITABILITY%20OF%20SOCIAL%20MISTRUST%20IN%20CHILD%20AND%20ADOLESCENT%20NON-CLINICAL%20SAMPLES:%20A%20HEALTHY%20TWINS%20STUDY&rft.jtitle=Schizophrenia%20bulletin&rft.au=Zhou,%20Han-yu&rft.date=2018-04-01&rft.volume=44&rft.issue=suppl_1&rft.spage=S333&rft.epage=S333&rft.pages=S333-S333&rft.issn=0586-7614&rft.eissn=1745-1701&rft_id=info:doi/10.1093/schbul/sby018.813&rft_dat=%3Coup_pubme%3E10.1093/schbul/sby018.813%3C/oup_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/schbul/sby018.813&rfr_iscdi=true