Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment

Tumour necrosis factor (TNF) is produced by primary human macrophages in response to stimulation by exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs) via Toll-like receptor (TLR) signalling. However, uncontrolled TNF production can b...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-05, Vol.499 (2), p.260-266
Hauptverfasser:	Page, Theresa H., Urbaniak, Anna M., Espirito Santo, Ana I., Danks, Lynett, Smallie, Timothy, Williams, Lynn M., Horwood, Nicole J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Agammaglobulinaemia Tyrosine Kinase Base Pairing - genetics Bruton's tyrosine kinase Cell Nucleus - metabolism Cytokines - biosynthesis Down-Regulation - genetics gene overexpression Humans Macrophages messenger RNA mitogen-activated protein kinase NF-kappa B - metabolism NFκB pathogen-associated molecular patterns Phosphorylation Promoter Regions, Genetic - genetics Protein-Tyrosine Kinases - metabolism R848 Toll-like receptor 4 Toll-Like Receptor 4 - metabolism Toll-Like Receptor 7 - metabolism Toll-Like Receptor 8 - metabolism Toll-like receptors-7/8 transcription (genetics) transcription factor NF-kappa B Transcription Factor RelA - metabolism Transcription, Genetic Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism tumor necrosis factors tyrosine
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