Enzyme Prodrug Therapy Achieves Site-Specific, Personalized Physiological Responses to the Locally Produced Nitric Oxide

Nitric oxide (NO) is a highly potent but short-lived endogenous radical with a wide spectrum of physiological activities. In this work, we developed an enzymatic approach to the site-specific synthesis of NO mediated by biocatalytic surface coatings. Multilayered polyelectrolyte films were optimized...

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Veröffentlicht in:	ACS applied materials & interfaces 2018-04, Vol.10 (13), p.10741-10751
Hauptverfasser:	Winther, Anna K, Fejerskov, Betina, ter Meer, Marja, Jensen, Najah B.S, Dillion, Ross, Schaffer, Jeremy E, Chandrawati, Rona, Stevens, Molly M, Schultze Kool, Leo J, Simonsen, Ulf, Zelikin, Alexander N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase Endothelium, Vascular Enzyme Inhibitors Enzymes, Immobilized Humans Nitric Oxide - analysis Prodrugs Rats Vasodilation
Online-Zugang:	Volltext
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