Selective Covalent Protein Modification by 4‐Halopyridines through Catalysis

We have investigated 4‐halopyridines as selective, tunable, and switchable covalent protein modifiers for use in the development of chemical probes. Nonenzymatic reactivity of 4‐chloropyridine with amino acids and thiols was ranked with respect to common covalent protein‐modifying reagents and found...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2017-08, Vol.18 (15), p.1551-1556
Hauptverfasser:	Schardon, Christopher L., Tuley, Alfred, Er, Joyce A. V., Swartzel, Jake C., Fast, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide Acrylamide - chemistry Affinity Affinity Labels - chemistry Amidohydrolases - chemistry Amino acids Catalysis Covalence covalent inhibitors covalent probes Cysteine Cysteine - chemistry Dimethylargininase E coli enzyme inactivation Escherichia coli - metabolism Glutathione - chemistry halopyridines Humans Iodoacetamide - chemistry Labels Phenols - chemistry Probes Proteins Proteome - chemistry Proteome - metabolism Pyridines - chemistry Pyridinium Pyridinium Compounds - chemistry Reactivity Reagents Stabilization Sulfhydryl Compounds - chemistry Thiols
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