Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules

Inherited mitochondrial optic neuropathies, such as Leber's hereditary optic neuropathy (LHON) and Autosomal dominant optic atrophy (ADOA) are caused by mutant mitochondrial proteins that lead to defects in mitochondrial complex 1-driven ATP synthesis, and cause specific retinal ganglion cell (...

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Veröffentlicht in:	Human molecular genetics 2017-12, Vol.26 (24), p.4929-4936
Hauptverfasser:	Yu, Alfred K, Datta, Sandipan, McMackin, Marissa Z, Cortopassi, Gino A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal DNA, Mitochondrial - metabolism Electron Transport Complex I - deficiency Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Glaucoma, Open-Angle - metabolism Humans Inflammation - metabolism Mediator Complex - metabolism Mice Mice, Knockout Mitochondria - metabolism Mitochondria - physiology Mitochondrial Diseases - metabolism Optic Nerve Diseases - genetics Optic Nerve Diseases - metabolism Papaverine - pharmacology Pyridines - pharmacology Retinal Ganglion Cells - metabolism Zolpidem
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