Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning
Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein that promotes directional cell migration and angiogenesis in vitro and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development in vivo , we generated the first knock...
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| creator | Shetty, Ronak Joshi, Divyesh Jain, Mamta Vasudevan, Madavan Paul, Jasper Chrysolite Bhat, Ganesh Banerjee, Poulomi Abe, Takaya Kiyonari, Hiroshi VijayRaghavan, K. Inamdar, Maneesha S. |
| description | Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein that promotes directional cell migration and angiogenesis
in vitro
and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development
in vivo
, we generated the first knockout mouse for
rudhira
and show that Rudhira is essential for mouse development.
Rudhira
null embryos die at embryonic day (E) 9.5 accompanied by severe vascular patterning defects in embryonic and extra-embryonic tissues. To identify the molecular processes downstream of
rudhira
, we analyzed the transcriptome of intact knockout yolk sacs. Genome-wide transcriptome analysis showed that Rudhira functions in angiogenesis and its related processes such as cell adhesion, extracellular matrix organization, peptidase activity and TGFβ signaling. Since Rudhira is also expressed in endothelial cells (ECs), we further generated Tie2Cre-mediated endothelial knockout (CKO) of
rudhira
. CKO embryos survive to E11.5 and similar to the global knockout, display gross vascular patterning defects, showing that endothelial Rudhira is vital for development. Further, Rudhira knockdown ECs in culture fail to sprout in a spheroid-sprouting assay, strongly supporting its role in vascular patterning. Our study identifies an essential role for Rudhira in blood vessel remodeling and provides a mouse model for cardiovascular development. |
| doi_str_mv | 10.1038/s41598-018-24014-w |
| format | Article |
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in vitro
and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development
in vivo
, we generated the first knockout mouse for
rudhira
and show that Rudhira is essential for mouse development.
Rudhira
null embryos die at embryonic day (E) 9.5 accompanied by severe vascular patterning defects in embryonic and extra-embryonic tissues. To identify the molecular processes downstream of
rudhira
, we analyzed the transcriptome of intact knockout yolk sacs. Genome-wide transcriptome analysis showed that Rudhira functions in angiogenesis and its related processes such as cell adhesion, extracellular matrix organization, peptidase activity and TGFβ signaling. Since Rudhira is also expressed in endothelial cells (ECs), we further generated Tie2Cre-mediated endothelial knockout (CKO) of
rudhira
. CKO embryos survive to E11.5 and similar to the global knockout, display gross vascular patterning defects, showing that endothelial Rudhira is vital for development. Further, Rudhira knockdown ECs in culture fail to sprout in a spheroid-sprouting assay, strongly supporting its role in vascular patterning. Our study identifies an essential role for Rudhira in blood vessel remodeling and provides a mouse model for cardiovascular development.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-24014-w</identifier><identifier>PMID: 29618843</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/1 ; 14 ; 14/19 ; 38 ; 38/61 ; 42 ; 42/109 ; 45 ; 45/41 ; 631/136/16/1456 ; 631/337/2019 ; 64/60 ; 82 ; 82/29 ; Angiogenesis ; Breast cancer ; Breast carcinoma ; Cardiovascular disease ; Cell adhesion ; Cell adhesion & migration ; Cell culture ; Cell migration ; Coronary artery ; Cytoskeleton ; Embryogenesis ; Embryos ; Endothelial cells ; Extracellular matrix ; Gene expression ; Genomes ; Heart diseases ; Humanities and Social Sciences ; multidisciplinary ; Pattern formation ; Peptidase ; Rodents ; Science ; Science (multidisciplinary) ; Yolk</subject><ispartof>Scientific reports, 2018-04, Vol.8 (1), p.5632-12, Article 5632</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-698514939ae9137b4341cfdc203e67fc04b2eac558bd6b64067ea3fe0cee9183</citedby><cites>FETCH-LOGICAL-c577t-698514939ae9137b4341cfdc203e67fc04b2eac558bd6b64067ea3fe0cee9183</cites><orcidid>0000-0002-8243-2821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884795/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884795/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27911,27912,41107,42176,51563,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29618843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shetty, Ronak</creatorcontrib><creatorcontrib>Joshi, Divyesh</creatorcontrib><creatorcontrib>Jain, Mamta</creatorcontrib><creatorcontrib>Vasudevan, Madavan</creatorcontrib><creatorcontrib>Paul, Jasper Chrysolite</creatorcontrib><creatorcontrib>Bhat, Ganesh</creatorcontrib><creatorcontrib>Banerjee, Poulomi</creatorcontrib><creatorcontrib>Abe, Takaya</creatorcontrib><creatorcontrib>Kiyonari, Hiroshi</creatorcontrib><creatorcontrib>VijayRaghavan, K.</creatorcontrib><creatorcontrib>Inamdar, Maneesha S.</creatorcontrib><title>Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein that promotes directional cell migration and angiogenesis
in vitro
and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development
in vivo
, we generated the first knockout mouse for
rudhira
and show that Rudhira is essential for mouse development.
Rudhira
null embryos die at embryonic day (E) 9.5 accompanied by severe vascular patterning defects in embryonic and extra-embryonic tissues. To identify the molecular processes downstream of
rudhira
, we analyzed the transcriptome of intact knockout yolk sacs. Genome-wide transcriptome analysis showed that Rudhira functions in angiogenesis and its related processes such as cell adhesion, extracellular matrix organization, peptidase activity and TGFβ signaling. Since Rudhira is also expressed in endothelial cells (ECs), we further generated Tie2Cre-mediated endothelial knockout (CKO) of
rudhira
. CKO embryos survive to E11.5 and similar to the global knockout, display gross vascular patterning defects, showing that endothelial Rudhira is vital for development. Further, Rudhira knockdown ECs in culture fail to sprout in a spheroid-sprouting assay, strongly supporting its role in vascular patterning. Our study identifies an essential role for Rudhira in blood vessel remodeling and provides a mouse model for cardiovascular development.</description><subject>13</subject><subject>13/1</subject><subject>14</subject><subject>14/19</subject><subject>38</subject><subject>38/61</subject><subject>42</subject><subject>42/109</subject><subject>45</subject><subject>45/41</subject><subject>631/136/16/1456</subject><subject>631/337/2019</subject><subject>64/60</subject><subject>82</subject><subject>82/29</subject><subject>Angiogenesis</subject><subject>Breast cancer</subject><subject>Breast carcinoma</subject><subject>Cardiovascular disease</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell culture</subject><subject>Cell migration</subject><subject>Coronary artery</subject><subject>Cytoskeleton</subject><subject>Embryogenesis</subject><subject>Embryos</subject><subject>Endothelial cells</subject><subject>Extracellular matrix</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Heart diseases</subject><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Pattern formation</subject><subject>Peptidase</subject><subject>Rodents</subject><subject>Science</subject><subject>Science 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Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8243-2821</orcidid></search><sort><creationdate>20180404</creationdate><title>Rudhira/BCAS3 is essential for mouse development and cardiovascular 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patterning</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-04-04</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>5632</spage><epage>12</epage><pages>5632-12</pages><artnum>5632</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein that promotes directional cell migration and angiogenesis
in vitro
and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development
in vivo
, we generated the first knockout mouse for
rudhira
and show that Rudhira is essential for mouse development.
Rudhira
null embryos die at embryonic day (E) 9.5 accompanied by severe vascular patterning defects in embryonic and extra-embryonic tissues. To identify the molecular processes downstream of
rudhira
, we analyzed the transcriptome of intact knockout yolk sacs. Genome-wide transcriptome analysis showed that Rudhira functions in angiogenesis and its related processes such as cell adhesion, extracellular matrix organization, peptidase activity and TGFβ signaling. Since Rudhira is also expressed in endothelial cells (ECs), we further generated Tie2Cre-mediated endothelial knockout (CKO) of
rudhira
. CKO embryos survive to E11.5 and similar to the global knockout, display gross vascular patterning defects, showing that endothelial Rudhira is vital for development. Further, Rudhira knockdown ECs in culture fail to sprout in a spheroid-sprouting assay, strongly supporting its role in vascular patterning. Our study identifies an essential role for Rudhira in blood vessel remodeling and provides a mouse model for cardiovascular development.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29618843</pmid><doi>10.1038/s41598-018-24014-w</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8243-2821</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 13 13/1 14 14/19 38 38/61 42 42/109 45 45/41 631/136/16/1456 631/337/2019 64/60 82 82/29 Angiogenesis Breast cancer Breast carcinoma Cardiovascular disease Cell adhesion Cell adhesion & migration Cell culture Cell migration Coronary artery Cytoskeleton Embryogenesis Embryos Endothelial cells Extracellular matrix Gene expression Genomes Heart diseases Humanities and Social Sciences multidisciplinary Pattern formation Peptidase Rodents Science Science (multidisciplinary) Yolk |
| title | Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning |
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