Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer

Purpose The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervous system. However, given that the BTB has increased passive permeability we hypothesize that liposomal irinotecan would improve local exposure of irinotecan and its active metabolite SN-38 in brain me...

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Veröffentlicht in:	Pharmaceutical research 2018-02, Vol.35 (2), p.31-10, Article 31
Hauptverfasser:	Mohammad, Afroz S., Griffith, Jessica I., Adkins, Chris E., Shah, Neal, Sechrest, Emily, Dolan, Emma L., Terrell-Hall, Tori B., Hendriks, Bart S., Lee, Helen, Lockman, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Blood Brain Brain cancer Breast cancer Central nervous system Controlled release Exposure Irinotecan Lesions Medical Law Metabolites Metastases Metastasis Permeability Pharmacology/Toxicology Pharmacy Research Paper Sustained release Toxicity Tumors
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