TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD

The expression and localization of transforming growth factor-β (TGF-β) pathway proteins in different compartments of the lower airways of patients with stable COPD is unclear. We aimed to determine TGF-β pathway protein expression in patients with stable COPD. The expression and localization of TGF...

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Veröffentlicht in:	Chest 2018-04, Vol.153 (4), p.851-862
Hauptverfasser:	Di Stefano, Antonino, Sangiorgi, Claudia, Gnemmi, Isabella, Casolari, Paolo, Brun, Paola, Ricciardolo, Fabio L.M., Contoli, Marco, Papi, Alberto, Maniscalco, Pio, Ruggeri, Paolo, Girbino, Giuseppe, Cappello, Francesco, Pavlides, Stelios, Guo, Yike, Chung, Kian Fan, Barnes, Peter J., Adcock, Ian M., Balbi, Bruno, Caramori, Gaetano
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged airway inflammation autoimmunity BAMBI Biomarkers - metabolism Bronchi - metabolism Case-Control Studies CTGF Female Humans Immunohistochemistry Lung - metabolism Macrophages, Alveolar - metabolism Male Membrane Proteins - metabolism Middle Aged Pulmonary Disease, Chronic Obstructive - metabolism Respiratory Mucosa - metabolism Signal Transduction - physiology SMAD Smad Proteins - metabolism TGF-β Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta3 - metabolism
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