Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy
Considerable attention has been focused on nonalcoholic fatty liver disease (NAFLD) which occasionally develops after pancreatoduodenectomy (PD). The present study aimed to clarify the prevalence, sequential change in properties and risk factors for NAFLD development after PD. We enrolled 196 patien...
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| Veröffentlicht in: | Annals of gastroenterological surgery 2017-09, Vol.1 (3), p.226-231 |
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| creator | Fujii, Yoshiro Nanashima, Atsushi Hiyoshi, Masahide Imamura, Naoya Yano, Koichi Hamada, Takeomi |
| description | Considerable attention has been focused on nonalcoholic fatty liver disease (NAFLD) which occasionally develops after pancreatoduodenectomy (PD). The present study aimed to clarify the prevalence, sequential change in properties and risk factors for NAFLD development after PD. We enrolled 196 patients who underwent PD and a computed tomography (CT) scan 1 month, 6 months and 1 year after surgery. NAFLD was defined as a liver‐to‐spleen attenuation ratio on plain CT of |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5881353</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2289384762</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4684-534810cfa28dfb4e07513ab73abcad190288d254451f02f91fe81879851f62ab3</originalsourceid><addsrcrecordid>eNp9kctKxDAUhoMoKurGB5CCGxFGc2ubbAQZvIEgeNkJIZOeaDRtxqQdmbc3OirqwkVIDvn4-Dk_QtsEHxCM6aF-SOyAUEz5ElqnvC5HmFGx_OO9hrZSesIYE0kqWrJVtEalqBjhZB3dX7v0XFht-hBTYUMsGpiBD9MWur4ItuhCp70Jj8E7k7m-nxfezSBzLoFOUGjb52mqOxNB96EZQgMdZF8730QrVvsEW5_3Bro7Pbkdn48ur84uxseXI8MrwUcl44JgYzUVjZ1wwHVJmJ7U-RjdEImpEA0tOS-JxdRKYkEQUUuR54rqCdtARwvvdJi00JgcPWqvptG1Os5V0E79_unco3oIM1UKQVjJsmDvUxDDywCpV61LBrzXHYQhKYq5lIxhKjO6-wd9CkPMO8oUFZIJXlc0U_sLysSQUgT7HYZg9d6beu9NffSW4Z2f8b_Rr5YyQBbAq_Mw_0eljs9u2EL6Bq9Jo1M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2289384762</pqid></control><display><type>article</type><title>Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy</title><source>Wiley Online Library Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Fujii, Yoshiro ; Nanashima, Atsushi ; Hiyoshi, Masahide ; Imamura, Naoya ; Yano, Koichi ; Hamada, Takeomi</creator><creatorcontrib>Fujii, Yoshiro ; Nanashima, Atsushi ; Hiyoshi, Masahide ; Imamura, Naoya ; Yano, Koichi ; Hamada, Takeomi</creatorcontrib><description>Considerable attention has been focused on nonalcoholic fatty liver disease (NAFLD) which occasionally develops after pancreatoduodenectomy (PD). The present study aimed to clarify the prevalence, sequential change in properties and risk factors for NAFLD development after PD. We enrolled 196 patients who underwent PD and a computed tomography (CT) scan 1 month, 6 months and 1 year after surgery. NAFLD was defined as a liver‐to‐spleen attenuation ratio on plain CT of <0.9. We compared various clinical factors between the NAFLD group and the control group. Individual prevalence of NAFLD at 1 month, 6 months and 1 year after surgery was 12%, 21% and 15%. Significantly different factors by univariate analysis were as follows: 1 month: age, sex, total protein (TP), total cholesterol (TC) and copper (Cu); 6 months: sex, disease, surgical method, portal vein resection (PVR), frequency of defecation, TC and Cu; 1 year: age, sex, disease, surgical method, PVR, frequency of defecation, TP and Cu. Risk factors by multivariate analysis were as follows: 1 month: not elderly age, female sex and a decrease in Cu; 6 months: female sex and a decrease in Cu; 1 year: a decrease in Cu. NAFLD after PD frequently developed in women with a decrease in serum Cu and was influenced by various factors related to poor digestion and absorption associated with pancreatic exocrine insufficiency.</description><identifier>ISSN: 2475-0328</identifier><identifier>EISSN: 2475-0328</identifier><identifier>DOI: 10.1002/ags3.12024</identifier><identifier>PMID: 29863141</identifier><language>eng</language><publisher>Japan: John Wiley & Sons, Inc</publisher><subject>Alcohol ; Blood tests ; Cancer therapies ; Diagnostic tests ; Enzymes ; Hospitals ; Insulin resistance ; Liver diseases ; Malnutrition ; nonalcoholic fatty liver disease ; Original ; Pancreaticoduodenectomy ; pancreatoduodenectomy ; Patients ; risk factor ; Risk factors ; Spleen ; Surgery ; Tumors</subject><ispartof>Annals of gastroenterological surgery, 2017-09, Vol.1 (3), p.226-231</ispartof><rights>2017 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4684-534810cfa28dfb4e07513ab73abcad190288d254451f02f91fe81879851f62ab3</citedby><cites>FETCH-LOGICAL-c4684-534810cfa28dfb4e07513ab73abcad190288d254451f02f91fe81879851f62ab3</cites><orcidid>0000-0002-7327-1106</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881353/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881353/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29863141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujii, Yoshiro</creatorcontrib><creatorcontrib>Nanashima, Atsushi</creatorcontrib><creatorcontrib>Hiyoshi, Masahide</creatorcontrib><creatorcontrib>Imamura, Naoya</creatorcontrib><creatorcontrib>Yano, Koichi</creatorcontrib><creatorcontrib>Hamada, Takeomi</creatorcontrib><title>Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy</title><title>Annals of gastroenterological surgery</title><addtitle>Ann Gastroenterol Surg</addtitle><description>Considerable attention has been focused on nonalcoholic fatty liver disease (NAFLD) which occasionally develops after pancreatoduodenectomy (PD). The present study aimed to clarify the prevalence, sequential change in properties and risk factors for NAFLD development after PD. We enrolled 196 patients who underwent PD and a computed tomography (CT) scan 1 month, 6 months and 1 year after surgery. NAFLD was defined as a liver‐to‐spleen attenuation ratio on plain CT of <0.9. We compared various clinical factors between the NAFLD group and the control group. Individual prevalence of NAFLD at 1 month, 6 months and 1 year after surgery was 12%, 21% and 15%. Significantly different factors by univariate analysis were as follows: 1 month: age, sex, total protein (TP), total cholesterol (TC) and copper (Cu); 6 months: sex, disease, surgical method, portal vein resection (PVR), frequency of defecation, TC and Cu; 1 year: age, sex, disease, surgical method, PVR, frequency of defecation, TP and Cu. Risk factors by multivariate analysis were as follows: 1 month: not elderly age, female sex and a decrease in Cu; 6 months: female sex and a decrease in Cu; 1 year: a decrease in Cu. NAFLD after PD frequently developed in women with a decrease in serum Cu and was influenced by various factors related to poor digestion and absorption associated with pancreatic exocrine insufficiency.</description><subject>Alcohol</subject><subject>Blood tests</subject><subject>Cancer therapies</subject><subject>Diagnostic tests</subject><subject>Enzymes</subject><subject>Hospitals</subject><subject>Insulin resistance</subject><subject>Liver diseases</subject><subject>Malnutrition</subject><subject>nonalcoholic fatty liver disease</subject><subject>Original</subject><subject>Pancreaticoduodenectomy</subject><subject>pancreatoduodenectomy</subject><subject>Patients</subject><subject>risk factor</subject><subject>Risk factors</subject><subject>Spleen</subject><subject>Surgery</subject><subject>Tumors</subject><issn>2475-0328</issn><issn>2475-0328</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctKxDAUhoMoKurGB5CCGxFGc2ubbAQZvIEgeNkJIZOeaDRtxqQdmbc3OirqwkVIDvn4-Dk_QtsEHxCM6aF-SOyAUEz5ElqnvC5HmFGx_OO9hrZSesIYE0kqWrJVtEalqBjhZB3dX7v0XFht-hBTYUMsGpiBD9MWur4ItuhCp70Jj8E7k7m-nxfezSBzLoFOUGjb52mqOxNB96EZQgMdZF8730QrVvsEW5_3Bro7Pbkdn48ur84uxseXI8MrwUcl44JgYzUVjZ1wwHVJmJ7U-RjdEImpEA0tOS-JxdRKYkEQUUuR54rqCdtARwvvdJi00JgcPWqvptG1Os5V0E79_unco3oIM1UKQVjJsmDvUxDDywCpV61LBrzXHYQhKYq5lIxhKjO6-wd9CkPMO8oUFZIJXlc0U_sLysSQUgT7HYZg9d6beu9NffSW4Z2f8b_Rr5YyQBbAq_Mw_0eljs9u2EL6Bq9Jo1M</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Fujii, Yoshiro</creator><creator>Nanashima, Atsushi</creator><creator>Hiyoshi, Masahide</creator><creator>Imamura, Naoya</creator><creator>Yano, Koichi</creator><creator>Hamada, Takeomi</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7327-1106</orcidid></search><sort><creationdate>201709</creationdate><title>Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy</title><author>Fujii, Yoshiro ; Nanashima, Atsushi ; Hiyoshi, Masahide ; Imamura, Naoya ; Yano, Koichi ; Hamada, Takeomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4684-534810cfa28dfb4e07513ab73abcad190288d254451f02f91fe81879851f62ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alcohol</topic><topic>Blood tests</topic><topic>Cancer therapies</topic><topic>Diagnostic tests</topic><topic>Enzymes</topic><topic>Hospitals</topic><topic>Insulin resistance</topic><topic>Liver diseases</topic><topic>Malnutrition</topic><topic>nonalcoholic fatty liver disease</topic><topic>Original</topic><topic>Pancreaticoduodenectomy</topic><topic>pancreatoduodenectomy</topic><topic>Patients</topic><topic>risk factor</topic><topic>Risk factors</topic><topic>Spleen</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujii, Yoshiro</creatorcontrib><creatorcontrib>Nanashima, Atsushi</creatorcontrib><creatorcontrib>Hiyoshi, Masahide</creatorcontrib><creatorcontrib>Imamura, Naoya</creatorcontrib><creatorcontrib>Yano, Koichi</creatorcontrib><creatorcontrib>Hamada, Takeomi</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of gastroenterological surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujii, Yoshiro</au><au>Nanashima, Atsushi</au><au>Hiyoshi, Masahide</au><au>Imamura, Naoya</au><au>Yano, Koichi</au><au>Hamada, Takeomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy</atitle><jtitle>Annals of gastroenterological surgery</jtitle><addtitle>Ann Gastroenterol Surg</addtitle><date>2017-09</date><risdate>2017</risdate><volume>1</volume><issue>3</issue><spage>226</spage><epage>231</epage><pages>226-231</pages><issn>2475-0328</issn><eissn>2475-0328</eissn><abstract>Considerable attention has been focused on nonalcoholic fatty liver disease (NAFLD) which occasionally develops after pancreatoduodenectomy (PD). The present study aimed to clarify the prevalence, sequential change in properties and risk factors for NAFLD development after PD. We enrolled 196 patients who underwent PD and a computed tomography (CT) scan 1 month, 6 months and 1 year after surgery. NAFLD was defined as a liver‐to‐spleen attenuation ratio on plain CT of <0.9. We compared various clinical factors between the NAFLD group and the control group. Individual prevalence of NAFLD at 1 month, 6 months and 1 year after surgery was 12%, 21% and 15%. Significantly different factors by univariate analysis were as follows: 1 month: age, sex, total protein (TP), total cholesterol (TC) and copper (Cu); 6 months: sex, disease, surgical method, portal vein resection (PVR), frequency of defecation, TC and Cu; 1 year: age, sex, disease, surgical method, PVR, frequency of defecation, TP and Cu. Risk factors by multivariate analysis were as follows: 1 month: not elderly age, female sex and a decrease in Cu; 6 months: female sex and a decrease in Cu; 1 year: a decrease in Cu. NAFLD after PD frequently developed in women with a decrease in serum Cu and was influenced by various factors related to poor digestion and absorption associated with pancreatic exocrine insufficiency.</abstract><cop>Japan</cop><pub>John Wiley & Sons, Inc</pub><pmid>29863141</pmid><doi>10.1002/ags3.12024</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7327-1106</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Blood tests Cancer therapies Diagnostic tests Enzymes Hospitals Insulin resistance Liver diseases Malnutrition nonalcoholic fatty liver disease Original Pancreaticoduodenectomy pancreatoduodenectomy Patients risk factor Risk factors Spleen Surgery Tumors |
| title | Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy |
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