Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease

OBJECTIVETo determine mechanisms underlying regional vulnerability to infarction in sickle cell disease (SCD) by measuring voxel-wise cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen utilization (CMRO2) in children with SCD. METHODSParticipants under...

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Veröffentlicht in:	Neurology 2018-03, Vol.90 (13), p.e1134-e1142
Hauptverfasser:	Fields, Melanie E, Guilliams, Kristin P, Ragan, Dustin K, Binkley, Michael M, Eldeniz, Cihat, Chen, Yasheng, Hulbert, Monica L, McKinstry, Robert C, Shimony, Joshua S, Vo, Katie D, Doctor, Allan, An, Hongyu, Ford, Andria L, Lee, Jin-Moo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anemia, Sickle Cell - diagnostic imaging Anemia, Sickle Cell - metabolism Anemia, Sickle Cell - therapy Brain - diagnostic imaging Brain - metabolism Cerebrovascular Circulation Child Child, Preschool Cohort Studies Female Humans Image Interpretation, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Oxygen - metabolism Oxygen Consumption Stroke - diagnostic imaging Stroke - metabolism Young Adult
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