MiR‐577 suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25
Background MicroRNAs can act as both tumor suppressor genes and oncogenes and participate in cell proliferation, metastasis, and apoptosis. Low levels of miR‐577 are found in several cancers, for example, thyroid carcinoma, glioblastoma, and hepatocellular carcinoma. The aim of this study was to inv...
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| Veröffentlicht in: | Thoracic cancer 2018-04, Vol.9 (4), p.472-479 |
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| creator | Yin, Chonggao Mou, Qingjie Pan, Xinting Zhang, Guoxin Li, Hongli Sun, Yunbo |
| description | Background
MicroRNAs can act as both tumor suppressor genes and oncogenes and participate in cell proliferation, metastasis, and apoptosis. Low levels of miR‐577 are found in several cancers, for example, thyroid carcinoma, glioblastoma, and hepatocellular carcinoma. The aim of this study was to investigate the effect of miR‐577 on breast cancer (BC).
Methods
The relative level of miR‐577 in 120 BC tissues and cells was detected by real‐time PCR. MDA‐MB‐231 cells with upregulated miR‐577 and MCF‐7 cells with downregulated miR‐577 were established. Transwell invasion assays were used to examine the invasiveness of cells. Epithelial‐mesenchymal transition (EMT) markers were evaluated by immunofluorescence and Western blot. Targeted combinations of miR‐577 and Rab25 were analyzed by luciferase assays. Xenograft models were used to examine the effect of miR‐577 on BC metastasis.
Results
MiR‐577 expression was significantly suppressed in BC tissues. Tumor size, tumor stage, and lymphatic metastasis were attributed to miR‐577 expression. Moreover, miR‐577 overexpression strongly inhibited the invasiveness and EMT of BC cells in vitro. MiR‐577 directly regulated Rab25 in BC. Rab25 upregulation by miR‐577 decreased the levels of E‐cadherin and increased the levels of Vimentin. Notably, Rab25 knockdown inhibited BC invasion; however, an increase in Rab25 counteracted the invasive effect of miR‐577 in BC.
Conclusion
Results indicated that miR‐577 suppressed EMT by inhibiting Rab25 expression in BC. MiR‐577 and Rab25 are considered potential targets of BC treatment. |
| doi_str_mv | 10.1111/1759-7714.12612 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5879053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A737043615</galeid><sourcerecordid>A737043615</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6002-e277027b03ba937b8504da5adf4103c96f09d15a93a1d4aef6562b04d5f7f9f73</originalsourceid><addsrcrecordid>eNqFkl1rFDEUhgex2NL22jsJeOPNbpPMZLK5EZbFL2gRSr0OmczJbupMMiYzlb3zJ_gb_SWe7dbVimASyMd5zpuc8BbFc0bnDNsFk0LNpGTVnPGa8SfFyeHk6WFN6-PiPOdbiq1cKMrFs-KYK8GrkqqT4vOVv_7x7buQkuRpGBLkDJnA4McNdN50GOshQ7CbbW86MiYTsh99DMSElvQwmozDZxIdaRLgjlgTLCTSbMlo0hpGH9bk2jRcnBVHznQZzh_m0-LT2zc3q_ezy4_vPqyWlzNbU8pnwPHVXDa0bIwqZbMQtGqNMK2rGC2tqh1VLRMYM6ytDLha1LxBRjjplJPlafF6rztMTQ-thYDP7vSQfG_SVkfj9eNI8Bu9jndaLKSiokSBVw8CKX6ZII-699lC15kAccqaU8YVq2lVIfryL_Q2TilgeZpzpaRaUCp_U2vTgfbBRbzX7kT1UpaSVmXNBFLzf1DYW-i9jQGcx_NHCRf7BJtizgncoUZG9c4iemcCvTOEvrcIZrz482sO_C9DICD2wFe8a_s_PX2zWu6FfwKhYsaR</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2299798007</pqid></control><display><type>article</type><title>MiR‐577 suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25</title><source>Wiley-Blackwell Open Access Collection</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley-Blackwell subscription journals</source><source>PubMed Central</source><source>EZB*</source><creator>Yin, Chonggao ; Mou, Qingjie ; Pan, Xinting ; Zhang, Guoxin ; Li, Hongli ; Sun, Yunbo</creator><creatorcontrib>Yin, Chonggao ; Mou, Qingjie ; Pan, Xinting ; Zhang, Guoxin ; Li, Hongli ; Sun, Yunbo</creatorcontrib><description>Background
MicroRNAs can act as both tumor suppressor genes and oncogenes and participate in cell proliferation, metastasis, and apoptosis. Low levels of miR‐577 are found in several cancers, for example, thyroid carcinoma, glioblastoma, and hepatocellular carcinoma. The aim of this study was to investigate the effect of miR‐577 on breast cancer (BC).
Methods
The relative level of miR‐577 in 120 BC tissues and cells was detected by real‐time PCR. MDA‐MB‐231 cells with upregulated miR‐577 and MCF‐7 cells with downregulated miR‐577 were established. Transwell invasion assays were used to examine the invasiveness of cells. Epithelial‐mesenchymal transition (EMT) markers were evaluated by immunofluorescence and Western blot. Targeted combinations of miR‐577 and Rab25 were analyzed by luciferase assays. Xenograft models were used to examine the effect of miR‐577 on BC metastasis.
Results
MiR‐577 expression was significantly suppressed in BC tissues. Tumor size, tumor stage, and lymphatic metastasis were attributed to miR‐577 expression. Moreover, miR‐577 overexpression strongly inhibited the invasiveness and EMT of BC cells in vitro. MiR‐577 directly regulated Rab25 in BC. Rab25 upregulation by miR‐577 decreased the levels of E‐cadherin and increased the levels of Vimentin. Notably, Rab25 knockdown inhibited BC invasion; however, an increase in Rab25 counteracted the invasive effect of miR‐577 in BC.
Conclusion
Results indicated that miR‐577 suppressed EMT by inhibiting Rab25 expression in BC. MiR‐577 and Rab25 are considered potential targets of BC treatment.</description><identifier>ISSN: 1759-7706</identifier><identifier>EISSN: 1759-7714</identifier><identifier>DOI: 10.1111/1759-7714.12612</identifier><identifier>PMID: 29524309</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Aged ; Analysis ; Apoptosis ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cell cycle ; Cell growth ; Cell Movement - genetics ; Cell Proliferation - genetics ; Colorectal cancer ; Deoxyribonucleic acid ; DNA ; Epithelial-Mesenchymal Transition - genetics ; epithelial‐mesenchymal transition ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Gliomas ; Humans ; Immunoglobulins ; Liver cancer ; Lymphatic Metastasis ; MCF-7 Cells ; Membranes ; Metastasis ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; MiR‐577 ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - pathology ; Original ; rab GTP-Binding Proteins - genetics ; Rab25 ; Stem cells ; Studies ; Thyroid cancer ; Thyroid diseases ; Tumors</subject><ispartof>Thoracic cancer, 2018-04, Vol.9 (4), p.472-479</ispartof><rights>2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd</rights><rights>2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6002-e277027b03ba937b8504da5adf4103c96f09d15a93a1d4aef6562b04d5f7f9f73</citedby><cites>FETCH-LOGICAL-c6002-e277027b03ba937b8504da5adf4103c96f09d15a93a1d4aef6562b04d5f7f9f73</cites><orcidid>0000-0001-6333-2270</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879053/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879053/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29524309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Chonggao</creatorcontrib><creatorcontrib>Mou, Qingjie</creatorcontrib><creatorcontrib>Pan, Xinting</creatorcontrib><creatorcontrib>Zhang, Guoxin</creatorcontrib><creatorcontrib>Li, Hongli</creatorcontrib><creatorcontrib>Sun, Yunbo</creatorcontrib><title>MiR‐577 suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25</title><title>Thoracic cancer</title><addtitle>Thorac Cancer</addtitle><description>Background
MicroRNAs can act as both tumor suppressor genes and oncogenes and participate in cell proliferation, metastasis, and apoptosis. Low levels of miR‐577 are found in several cancers, for example, thyroid carcinoma, glioblastoma, and hepatocellular carcinoma. The aim of this study was to investigate the effect of miR‐577 on breast cancer (BC).
Methods
The relative level of miR‐577 in 120 BC tissues and cells was detected by real‐time PCR. MDA‐MB‐231 cells with upregulated miR‐577 and MCF‐7 cells with downregulated miR‐577 were established. Transwell invasion assays were used to examine the invasiveness of cells. Epithelial‐mesenchymal transition (EMT) markers were evaluated by immunofluorescence and Western blot. Targeted combinations of miR‐577 and Rab25 were analyzed by luciferase assays. Xenograft models were used to examine the effect of miR‐577 on BC metastasis.
Results
MiR‐577 expression was significantly suppressed in BC tissues. Tumor size, tumor stage, and lymphatic metastasis were attributed to miR‐577 expression. Moreover, miR‐577 overexpression strongly inhibited the invasiveness and EMT of BC cells in vitro. MiR‐577 directly regulated Rab25 in BC. Rab25 upregulation by miR‐577 decreased the levels of E‐cadherin and increased the levels of Vimentin. Notably, Rab25 knockdown inhibited BC invasion; however, an increase in Rab25 counteracted the invasive effect of miR‐577 in BC.
Conclusion
Results indicated that miR‐577 suppressed EMT by inhibiting Rab25 expression in BC. MiR‐577 and Rab25 are considered potential targets of BC treatment.</description><subject>Aged</subject><subject>Analysis</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Colorectal cancer</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>epithelial‐mesenchymal transition</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Knockdown Techniques</subject><subject>Gliomas</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Liver cancer</subject><subject>Lymphatic Metastasis</subject><subject>MCF-7 Cells</subject><subject>Membranes</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>MiR‐577</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Original</subject><subject>rab GTP-Binding Proteins - genetics</subject><subject>Rab25</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Thyroid cancer</subject><subject>Thyroid diseases</subject><subject>Tumors</subject><issn>1759-7706</issn><issn>1759-7714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkl1rFDEUhgex2NL22jsJeOPNbpPMZLK5EZbFL2gRSr0OmczJbupMMiYzlb3zJ_gb_SWe7dbVimASyMd5zpuc8BbFc0bnDNsFk0LNpGTVnPGa8SfFyeHk6WFN6-PiPOdbiq1cKMrFs-KYK8GrkqqT4vOVv_7x7buQkuRpGBLkDJnA4McNdN50GOshQ7CbbW86MiYTsh99DMSElvQwmozDZxIdaRLgjlgTLCTSbMlo0hpGH9bk2jRcnBVHznQZzh_m0-LT2zc3q_ezy4_vPqyWlzNbU8pnwPHVXDa0bIwqZbMQtGqNMK2rGC2tqh1VLRMYM6ytDLha1LxBRjjplJPlafF6rztMTQ-thYDP7vSQfG_SVkfj9eNI8Bu9jndaLKSiokSBVw8CKX6ZII-699lC15kAccqaU8YVq2lVIfryL_Q2TilgeZpzpaRaUCp_U2vTgfbBRbzX7kT1UpaSVmXNBFLzf1DYW-i9jQGcx_NHCRf7BJtizgncoUZG9c4iemcCvTOEvrcIZrz482sO_C9DICD2wFe8a_s_PX2zWu6FfwKhYsaR</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Yin, Chonggao</creator><creator>Mou, Qingjie</creator><creator>Pan, Xinting</creator><creator>Zhang, Guoxin</creator><creator>Li, Hongli</creator><creator>Sun, Yunbo</creator><general>John Wiley & Sons Australia, Ltd</general><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6333-2270</orcidid></search><sort><creationdate>201804</creationdate><title>MiR‐577 suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25</title><author>Yin, Chonggao ; Mou, Qingjie ; Pan, Xinting ; Zhang, Guoxin ; Li, Hongli ; Sun, Yunbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6002-e277027b03ba937b8504da5adf4103c96f09d15a93a1d4aef6562b04d5f7f9f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation - genetics</topic><topic>Colorectal cancer</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>epithelial‐mesenchymal transition</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>Gliomas</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Liver cancer</topic><topic>Lymphatic Metastasis</topic><topic>MCF-7 Cells</topic><topic>Membranes</topic><topic>Metastasis</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>MiR‐577</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Original</topic><topic>rab GTP-Binding Proteins - genetics</topic><topic>Rab25</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Thyroid cancer</topic><topic>Thyroid diseases</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Chonggao</creatorcontrib><creatorcontrib>Mou, Qingjie</creatorcontrib><creatorcontrib>Pan, Xinting</creatorcontrib><creatorcontrib>Zhang, Guoxin</creatorcontrib><creatorcontrib>Li, Hongli</creatorcontrib><creatorcontrib>Sun, Yunbo</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thoracic cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Chonggao</au><au>Mou, Qingjie</au><au>Pan, Xinting</au><au>Zhang, Guoxin</au><au>Li, Hongli</au><au>Sun, Yunbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR‐577 suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25</atitle><jtitle>Thoracic cancer</jtitle><addtitle>Thorac Cancer</addtitle><date>2018-04</date><risdate>2018</risdate><volume>9</volume><issue>4</issue><spage>472</spage><epage>479</epage><pages>472-479</pages><issn>1759-7706</issn><eissn>1759-7714</eissn><abstract>Background
MicroRNAs can act as both tumor suppressor genes and oncogenes and participate in cell proliferation, metastasis, and apoptosis. Low levels of miR‐577 are found in several cancers, for example, thyroid carcinoma, glioblastoma, and hepatocellular carcinoma. The aim of this study was to investigate the effect of miR‐577 on breast cancer (BC).
Methods
The relative level of miR‐577 in 120 BC tissues and cells was detected by real‐time PCR. MDA‐MB‐231 cells with upregulated miR‐577 and MCF‐7 cells with downregulated miR‐577 were established. Transwell invasion assays were used to examine the invasiveness of cells. Epithelial‐mesenchymal transition (EMT) markers were evaluated by immunofluorescence and Western blot. Targeted combinations of miR‐577 and Rab25 were analyzed by luciferase assays. Xenograft models were used to examine the effect of miR‐577 on BC metastasis.
Results
MiR‐577 expression was significantly suppressed in BC tissues. Tumor size, tumor stage, and lymphatic metastasis were attributed to miR‐577 expression. Moreover, miR‐577 overexpression strongly inhibited the invasiveness and EMT of BC cells in vitro. MiR‐577 directly regulated Rab25 in BC. Rab25 upregulation by miR‐577 decreased the levels of E‐cadherin and increased the levels of Vimentin. Notably, Rab25 knockdown inhibited BC invasion; however, an increase in Rab25 counteracted the invasive effect of miR‐577 in BC.
Conclusion
Results indicated that miR‐577 suppressed EMT by inhibiting Rab25 expression in BC. MiR‐577 and Rab25 are considered potential targets of BC treatment.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>29524309</pmid><doi>10.1111/1759-7714.12612</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6333-2270</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Open Access Collection; MEDLINE; DOAJ Directory of Open Access Journals; Wiley-Blackwell subscription journals; PubMed Central; EZB* |
| subjects | Aged Analysis Apoptosis Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cell cycle Cell growth Cell Movement - genetics Cell Proliferation - genetics Colorectal cancer Deoxyribonucleic acid DNA Epithelial-Mesenchymal Transition - genetics epithelial‐mesenchymal transition Female Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Gliomas Humans Immunoglobulins Liver cancer Lymphatic Metastasis MCF-7 Cells Membranes Metastasis MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged MiR‐577 Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Original rab GTP-Binding Proteins - genetics Rab25 Stem cells Studies Thyroid cancer Thyroid diseases Tumors |
| title | MiR‐577 suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25 |
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