Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response
Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essent...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-10 |
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| creator | Cuman, Roberto Kenji Nakamura Bersani-Amado, Ciomar Aparecida Salvadego, Valter Eduardo Cocco Cassarotti, Larissa Laila Cavalcante, Heitor Augusto Otaviano Uchida, Nancy Sayuri Silva, Expedito Leite Silva-Filho, Saulo Euclides Cardia, Gabriel Fernando Esteves Spironello, Ricardo Alexandre |
| description | Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 μg/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine. |
| doi_str_mv | 10.1155/2018/1413940 |
| format | Article |
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The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 μg/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/1413940</identifier><identifier>PMID: 29743918</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Allergies ; Alzheimer's disease ; Analysis ; Animals ; Anti-inflammatory agents ; Anti-inflammatory drugs ; Anticonvulsants ; Antioxidants ; Aromatherapy ; Biological properties ; Borneol ; Camphor ; Carrageenan ; Carrageenin ; Chemotaxis ; Cineole ; Cytokines ; Cytotoxicity ; Dextran ; Ear ; Edema ; Essential oils ; Gas chromatography ; Health aspects ; Herbal medicine ; Histamine ; Inflammation ; Inflammatory response ; Lamiaceae ; Lavandula angustifolia ; Magnetic resonance spectroscopy ; Mass spectrometry ; Mass spectroscopy ; Natural products ; Nitric oxide ; NMR ; Nuclear magnetic resonance ; Nuclear magnetic resonance spectroscopy ; Oils & fats ; Peroxidase ; Pharmacology ; Povidone ; Prostaglandins ; Rodents ; Topical application</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-10</ispartof><rights>Copyright © 2018 Gabriel Fernando Esteves Cardia et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Gabriel Fernando Esteves Cardia et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Gabriel Fernando Esteves Cardia et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-64fb8508e7f3defe3d67861c1144b4c817e441ef31c1fa3a3b03acb9d8728f773</citedby><cites>FETCH-LOGICAL-c499t-64fb8508e7f3defe3d67861c1144b4c817e441ef31c1fa3a3b03acb9d8728f773</cites><orcidid>0000-0002-9676-7622 ; 0000-0002-5975-0063 ; 0000-0003-1586-4111 ; 0000-0002-4906-887X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878871/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878871/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29743918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Xu, Junji</contributor><contributor>Junji Xu</contributor><creatorcontrib>Cuman, Roberto Kenji Nakamura</creatorcontrib><creatorcontrib>Bersani-Amado, Ciomar Aparecida</creatorcontrib><creatorcontrib>Salvadego, Valter Eduardo Cocco</creatorcontrib><creatorcontrib>Cassarotti, Larissa Laila</creatorcontrib><creatorcontrib>Cavalcante, Heitor Augusto Otaviano</creatorcontrib><creatorcontrib>Uchida, Nancy Sayuri</creatorcontrib><creatorcontrib>Silva, Expedito Leite</creatorcontrib><creatorcontrib>Silva-Filho, Saulo Euclides</creatorcontrib><creatorcontrib>Cardia, Gabriel Fernando Esteves</creatorcontrib><creatorcontrib>Spironello, Ricardo Alexandre</creatorcontrib><title>Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 μg/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine.</description><subject>Allergies</subject><subject>Alzheimer's disease</subject><subject>Analysis</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Anti-inflammatory drugs</subject><subject>Anticonvulsants</subject><subject>Antioxidants</subject><subject>Aromatherapy</subject><subject>Biological properties</subject><subject>Borneol</subject><subject>Camphor</subject><subject>Carrageenan</subject><subject>Carrageenin</subject><subject>Chemotaxis</subject><subject>Cineole</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Dextran</subject><subject>Ear</subject><subject>Edema</subject><subject>Essential oils</subject><subject>Gas chromatography</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Histamine</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Lamiaceae</subject><subject>Lavandula angustifolia</subject><subject>Magnetic resonance spectroscopy</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Natural products</subject><subject>Nitric oxide</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear magnetic resonance spectroscopy</subject><subject>Oils & fats</subject><subject>Peroxidase</subject><subject>Pharmacology</subject><subject>Povidone</subject><subject>Prostaglandins</subject><subject>Rodents</subject><subject>Topical 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of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response</title><author>Cuman, Roberto Kenji Nakamura ; Bersani-Amado, Ciomar Aparecida ; Salvadego, Valter Eduardo Cocco ; Cassarotti, Larissa Laila ; Cavalcante, Heitor Augusto Otaviano ; Uchida, Nancy Sayuri ; Silva, Expedito Leite ; Silva-Filho, Saulo Euclides ; Cardia, Gabriel Fernando Esteves ; Spironello, Ricardo Alexandre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-64fb8508e7f3defe3d67861c1144b4c817e441ef31c1fa3a3b03acb9d8728f773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Allergies</topic><topic>Alzheimer's disease</topic><topic>Analysis</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Anti-inflammatory drugs</topic><topic>Anticonvulsants</topic><topic>Antioxidants</topic><topic>Aromatherapy</topic><topic>Biological properties</topic><topic>Borneol</topic><topic>Camphor</topic><topic>Carrageenan</topic><topic>Carrageenin</topic><topic>Chemotaxis</topic><topic>Cineole</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Dextran</topic><topic>Ear</topic><topic>Edema</topic><topic>Essential oils</topic><topic>Gas chromatography</topic><topic>Health aspects</topic><topic>Herbal medicine</topic><topic>Histamine</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Lamiaceae</topic><topic>Lavandula angustifolia</topic><topic>Magnetic resonance spectroscopy</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Natural products</topic><topic>Nitric oxide</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclear magnetic resonance spectroscopy</topic><topic>Oils & fats</topic><topic>Peroxidase</topic><topic>Pharmacology</topic><topic>Povidone</topic><topic>Prostaglandins</topic><topic>Rodents</topic><topic>Topical 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Xu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 μg/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29743918</pmid><doi>10.1155/2018/1413940</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9676-7622</orcidid><orcidid>https://orcid.org/0000-0002-5975-0063</orcidid><orcidid>https://orcid.org/0000-0003-1586-4111</orcidid><orcidid>https://orcid.org/0000-0002-4906-887X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-10 |
| issn | 1741-427X 1741-4288 |
| language | eng |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Allergies Alzheimer's disease Analysis Animals Anti-inflammatory agents Anti-inflammatory drugs Anticonvulsants Antioxidants Aromatherapy Biological properties Borneol Camphor Carrageenan Carrageenin Chemotaxis Cineole Cytokines Cytotoxicity Dextran Ear Edema Essential oils Gas chromatography Health aspects Herbal medicine Histamine Inflammation Inflammatory response Lamiaceae Lavandula angustifolia Magnetic resonance spectroscopy Mass spectrometry Mass spectroscopy Natural products Nitric oxide NMR Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Oils & fats Peroxidase Pharmacology Povidone Prostaglandins Rodents Topical application |
| title | Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response |
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