Mesenchymal Stromal Cell Therapy for Pancreatitis: A Systematic Review
Background. Based on animal studies, adult mesenchymal stromal cells (MSCs) are promising for the treatment of pancreatitis. However, the best type of this form of cell therapy and its mechanism of action remain unclear. Methods. We searched the PubMed, Web of Science, Scopus, Google Scholar, and Cl...
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| creator | Abdel-Daim, Mohamed M. Ghoneim, Nehal I. Morsi, Mahmoud Ahmed, Sara M. El-Badri, Nagwa |
| description | Background. Based on animal studies, adult mesenchymal stromal cells (MSCs) are promising for the treatment of pancreatitis. However, the best type of this form of cell therapy and its mechanism of action remain unclear. Methods. We searched the PubMed, Web of Science, Scopus, Google Scholar, and Clinical Trials.gov websites for studies using MSCs as a therapy for both acute and chronic pancreatitis published until September 2017. Results. We identified 276 publications; of these publications, 18 met our inclusion criteria. In animal studies, stem cell therapy was applied more frequently for acute pancreatitis than for chronic pancreatitis. No clinical trials were identified. MSC therapy ameliorated pancreatic inflammation in acute pancreatitis and pancreatic fibrosis in chronic pancreatitis. Bone marrow and umbilical cord MSCs were the most frequently administered cell types. Due to the substantial heterogeneity among the studies regarding the type, source, and dose of MSCs used, conducting a meta-analysis was not feasible to determine the best type of MSCs. Conclusion. The available data were insufficient for determining the best type of MSCs for the treatment of acute or chronic pancreatitis; therefore, clinical trials investigating the use of MSCs as therapy for pancreatitis are not warranted. |
| doi_str_mv | 10.1155/2018/3250864 |
| format | Article |
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Based on animal studies, adult mesenchymal stromal cells (MSCs) are promising for the treatment of pancreatitis. However, the best type of this form of cell therapy and its mechanism of action remain unclear. Methods. We searched the PubMed, Web of Science, Scopus, Google Scholar, and Clinical Trials.gov websites for studies using MSCs as a therapy for both acute and chronic pancreatitis published until September 2017. Results. We identified 276 publications; of these publications, 18 met our inclusion criteria. In animal studies, stem cell therapy was applied more frequently for acute pancreatitis than for chronic pancreatitis. No clinical trials were identified. MSC therapy ameliorated pancreatic inflammation in acute pancreatitis and pancreatic fibrosis in chronic pancreatitis. Bone marrow and umbilical cord MSCs were the most frequently administered cell types. Due to the substantial heterogeneity among the studies regarding the type, source, and dose of MSCs used, conducting a meta-analysis was not feasible to determine the best type of MSCs. Conclusion. The available data were insufficient for determining the best type of MSCs for the treatment of acute or chronic pancreatitis; therefore, clinical trials investigating the use of MSCs as therapy for pancreatitis are not warranted.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2018/3250864</identifier><identifier>PMID: 29743979</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Angiogenesis ; Animals ; Bone marrow ; Cell growth ; Cell- and Tissue-Based Therapy - methods ; Cytokines ; Disease Models, Animal ; Gene expression ; Humans ; Hypotheses ; Inflammation ; Medical research ; Medicine, Experimental ; Mesenchymal Stem Cells - metabolism ; Mortality ; Pancreatitis ; Pancreatitis, Chronic - genetics ; Pancreatitis, Chronic - metabolism ; Pancreatitis, Chronic - therapy ; Review ; Stem cells ; Studies ; Transplantation ; Tumor necrosis factor-TNF ; Umbilical cord</subject><ispartof>Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-14</ispartof><rights>Copyright © 2018 Sara M. Ahmed et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Sara M. Ahmed et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Sara M. Ahmed et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-a33917360b7f8eb7193d06939a3ca9411fb9c398fdb800ecf7aba2a9f5b6a4e03</citedby><cites>FETCH-LOGICAL-c499t-a33917360b7f8eb7193d06939a3ca9411fb9c398fdb800ecf7aba2a9f5b6a4e03</cites><orcidid>0000-0002-6621-0751 ; 0000-0002-1965-611X ; 0000-0002-4341-2713</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878867/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878867/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29743979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Maraldi, Tullia</contributor><contributor>Tullia Maraldi</contributor><creatorcontrib>Abdel-Daim, Mohamed M.</creatorcontrib><creatorcontrib>Ghoneim, Nehal I.</creatorcontrib><creatorcontrib>Morsi, Mahmoud</creatorcontrib><creatorcontrib>Ahmed, Sara M.</creatorcontrib><creatorcontrib>El-Badri, Nagwa</creatorcontrib><title>Mesenchymal Stromal Cell Therapy for Pancreatitis: A Systematic Review</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Background. Based on animal studies, adult mesenchymal stromal cells (MSCs) are promising for the treatment of pancreatitis. However, the best type of this form of cell therapy and its mechanism of action remain unclear. Methods. We searched the PubMed, Web of Science, Scopus, Google Scholar, and Clinical Trials.gov websites for studies using MSCs as a therapy for both acute and chronic pancreatitis published until September 2017. Results. We identified 276 publications; of these publications, 18 met our inclusion criteria. In animal studies, stem cell therapy was applied more frequently for acute pancreatitis than for chronic pancreatitis. No clinical trials were identified. MSC therapy ameliorated pancreatic inflammation in acute pancreatitis and pancreatic fibrosis in chronic pancreatitis. Bone marrow and umbilical cord MSCs were the most frequently administered cell types. Due to the substantial heterogeneity among the studies regarding the type, source, and dose of MSCs used, conducting a meta-analysis was not feasible to determine the best type of MSCs. Conclusion. The available data were insufficient for determining the best type of MSCs for the treatment of acute or chronic pancreatitis; therefore, clinical trials investigating the use of MSCs as therapy for pancreatitis are not warranted.</description><subject>Analysis</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Bone marrow</subject><subject>Cell growth</subject><subject>Cell- and Tissue-Based Therapy - methods</subject><subject>Cytokines</subject><subject>Disease Models, Animal</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Inflammation</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mesenchymal Stem Cells - metabolism</subject><subject>Mortality</subject><subject>Pancreatitis</subject><subject>Pancreatitis, Chronic - genetics</subject><subject>Pancreatitis, Chronic - metabolism</subject><subject>Pancreatitis, Chronic - therapy</subject><subject>Review</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Transplantation</subject><subject>Tumor necrosis factor-TNF</subject><subject>Umbilical cord</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1vEzEQxS0EoqVw44xW4oIEoeOPtXc4IEVRC0hFIFrO1qzjbVztR7A3rfLf16uEUDhxGlv-6b15foy95PCe87I8FcCrUylKqLR6xI45KjEDRPX4cAY4Ys9SugHQUij-lB0JNEqiwWN2_tUn37vVtqO2uBzjMM2Fb9viauUjrbdFM8TiO_UuehrDGNKHYl5cbtPou3x3xQ9_G_zdc_akoTb5F_t5wn6en10tPs8uvn36sphfzJxCHGckJXIjNdSmqXxtOMolaJRI0hEqzpsancSqWdYVgHeNoZoEYVPWmpQHecI-7nTXm7rzS-f7MVJr1zF0FLd2oGD_funDyl4Pt7asTFVpkwXe7AXi8Gvj02i7kFzOS70fNskKkAZKjTh5vf4HvRk2sc_xMiVA5c-EB9Q1td6Gvhmyr5tE7VyDMNxowEy921EuDilF3xxW5mCnGu1Uo93XmPFXD2Me4N-9ZeDtDliFfkl34T_lcmfZm_7QgnOOlbwH3QitXA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Abdel-Daim, Mohamed M.</creator><creator>Ghoneim, Nehal I.</creator><creator>Morsi, Mahmoud</creator><creator>Ahmed, Sara M.</creator><creator>El-Badri, Nagwa</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6621-0751</orcidid><orcidid>https://orcid.org/0000-0002-1965-611X</orcidid><orcidid>https://orcid.org/0000-0002-4341-2713</orcidid></search><sort><creationdate>20180101</creationdate><title>Mesenchymal Stromal Cell Therapy for Pancreatitis: A Systematic Review</title><author>Abdel-Daim, Mohamed M. ; Ghoneim, Nehal I. ; Morsi, Mahmoud ; Ahmed, Sara M. ; El-Badri, Nagwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-a33917360b7f8eb7193d06939a3ca9411fb9c398fdb800ecf7aba2a9f5b6a4e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Bone marrow</topic><topic>Cell growth</topic><topic>Cell- and Tissue-Based Therapy - methods</topic><topic>Cytokines</topic><topic>Disease Models, Animal</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Inflammation</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mesenchymal Stem Cells - metabolism</topic><topic>Mortality</topic><topic>Pancreatitis</topic><topic>Pancreatitis, Chronic - genetics</topic><topic>Pancreatitis, Chronic - metabolism</topic><topic>Pancreatitis, Chronic - therapy</topic><topic>Review</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Transplantation</topic><topic>Tumor necrosis factor-TNF</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Daim, Mohamed M.</creatorcontrib><creatorcontrib>Ghoneim, Nehal I.</creatorcontrib><creatorcontrib>Morsi, Mahmoud</creatorcontrib><creatorcontrib>Ahmed, Sara M.</creatorcontrib><creatorcontrib>El-Badri, Nagwa</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Daim, Mohamed M.</au><au>Ghoneim, Nehal I.</au><au>Morsi, Mahmoud</au><au>Ahmed, Sara M.</au><au>El-Badri, Nagwa</au><au>Maraldi, Tullia</au><au>Tullia Maraldi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesenchymal Stromal Cell Therapy for Pancreatitis: A Systematic Review</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Background. Based on animal studies, adult mesenchymal stromal cells (MSCs) are promising for the treatment of pancreatitis. However, the best type of this form of cell therapy and its mechanism of action remain unclear. Methods. We searched the PubMed, Web of Science, Scopus, Google Scholar, and Clinical Trials.gov websites for studies using MSCs as a therapy for both acute and chronic pancreatitis published until September 2017. Results. We identified 276 publications; of these publications, 18 met our inclusion criteria. In animal studies, stem cell therapy was applied more frequently for acute pancreatitis than for chronic pancreatitis. No clinical trials were identified. MSC therapy ameliorated pancreatic inflammation in acute pancreatitis and pancreatic fibrosis in chronic pancreatitis. Bone marrow and umbilical cord MSCs were the most frequently administered cell types. Due to the substantial heterogeneity among the studies regarding the type, source, and dose of MSCs used, conducting a meta-analysis was not feasible to determine the best type of MSCs. Conclusion. The available data were insufficient for determining the best type of MSCs for the treatment of acute or chronic pancreatitis; therefore, clinical trials investigating the use of MSCs as therapy for pancreatitis are not warranted.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29743979</pmid><doi>10.1155/2018/3250864</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-6621-0751</orcidid><orcidid>https://orcid.org/0000-0002-1965-611X</orcidid><orcidid>https://orcid.org/0000-0002-4341-2713</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Angiogenesis Animals Bone marrow Cell growth Cell- and Tissue-Based Therapy - methods Cytokines Disease Models, Animal Gene expression Humans Hypotheses Inflammation Medical research Medicine, Experimental Mesenchymal Stem Cells - metabolism Mortality Pancreatitis Pancreatitis, Chronic - genetics Pancreatitis, Chronic - metabolism Pancreatitis, Chronic - therapy Review Stem cells Studies Transplantation Tumor necrosis factor-TNF Umbilical cord |
| title | Mesenchymal Stromal Cell Therapy for Pancreatitis: A Systematic Review |
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