Association Between Carotid Intima Media Thickness, Age, and Cardiovascular Risk Factors in Children and Adolescents
Measures of carotid intima media thickness (cIMT) in adults are correlated with adiposity and the metabolic syndrome (MetS) and predict cardiovascular (CV) events. Relations in children are not as well studied. Our objective was to determine the relations of cIMT with body mass index (BMI) and CV ri...
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| Veröffentlicht in: | Metabolic syndrome and related disorders 2018-04, Vol.16 (3), p.122-126 |
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| creator | Gooty, Vasu D Sinaiko, Alan R Ryder, Justin R Dengel, Donald R Jacobs, Jr, David R Steinberger, Julia |
| description | Measures of carotid intima media thickness (cIMT) in adults are correlated with adiposity and the metabolic syndrome (MetS) and predict cardiovascular (CV) events. Relations in children are not as well studied. Our objective was to determine the relations of cIMT with body mass index (BMI) and CV risk score in children.
The study included 291 children (158 M/133 F) 6-18 years of age (140 aged 6-11/151 aged 12-18) with measurements of height, weight, waist circumference; fasting lipids, glucose, insulin, and cIMT. A CV risk cluster score was developed from sum of the z-scores of the five MetS components (waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and insulin). Partial Pearson correlation coefficients were adjusted for age, sex, and race.
There was no significant age difference in cIMT from 6 to 18 years of age. BMI and CV risk score were significantly correlated (P |
| doi_str_mv | 10.1089/met.2017.0149 |
| format | Article |
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The study included 291 children (158 M/133 F) 6-18 years of age (140 aged 6-11/151 aged 12-18) with measurements of height, weight, waist circumference; fasting lipids, glucose, insulin, and cIMT. A CV risk cluster score was developed from sum of the z-scores of the five MetS components (waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and insulin). Partial Pearson correlation coefficients were adjusted for age, sex, and race.
There was no significant age difference in cIMT from 6 to 18 years of age. BMI and CV risk score were significantly correlated (P < 0.0001), and both were correlated with cIMT (r = 0.14, P = 0.02 and r = 0.16, P = 0.006, respectively). Slight age-related differences in associations of cIMT with CV risk score and BMI were explained by unusual values in a few children.
These cross-sectional data in normal children show that cIMT was stable from childhood into adolescence. However, both BMI and CV risk score had small, but significant positive correlations with cIMT. Therefore, maintaining normal levels of adiposity and other risk variables may be useful in preventing early changes associated with preclinical atherosclerosis.</description><identifier>ISSN: 1540-4196</identifier><identifier>EISSN: 1557-8518</identifier><identifier>DOI: 10.1089/met.2017.0149</identifier><identifier>PMID: 29412763</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adolescent ; Age Factors ; Age of Onset ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Carotid Intima-Media Thickness ; Child ; Child Development - physiology ; Cross-Sectional Studies ; Female ; Humans ; Longitudinal Studies ; Male ; Original ; Risk Factors</subject><ispartof>Metabolic syndrome and related disorders, 2018-04, Vol.16 (3), p.122-126</ispartof><rights>Copyright 2018, Mary Ann Liebert, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-a614dab8aa1c10caf328e80ae5941a58ceaed5391c69a99a905c7e19fb1633283</citedby><cites>FETCH-LOGICAL-c387t-a614dab8aa1c10caf328e80ae5941a58ceaed5391c69a99a905c7e19fb1633283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29412763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gooty, Vasu D</creatorcontrib><creatorcontrib>Sinaiko, Alan R</creatorcontrib><creatorcontrib>Ryder, Justin R</creatorcontrib><creatorcontrib>Dengel, Donald R</creatorcontrib><creatorcontrib>Jacobs, Jr, David R</creatorcontrib><creatorcontrib>Steinberger, Julia</creatorcontrib><title>Association Between Carotid Intima Media Thickness, Age, and Cardiovascular Risk Factors in Children and Adolescents</title><title>Metabolic syndrome and related disorders</title><addtitle>Metab Syndr Relat Disord</addtitle><description>Measures of carotid intima media thickness (cIMT) in adults are correlated with adiposity and the metabolic syndrome (MetS) and predict cardiovascular (CV) events. Relations in children are not as well studied. Our objective was to determine the relations of cIMT with body mass index (BMI) and CV risk score in children.
The study included 291 children (158 M/133 F) 6-18 years of age (140 aged 6-11/151 aged 12-18) with measurements of height, weight, waist circumference; fasting lipids, glucose, insulin, and cIMT. A CV risk cluster score was developed from sum of the z-scores of the five MetS components (waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and insulin). Partial Pearson correlation coefficients were adjusted for age, sex, and race.
There was no significant age difference in cIMT from 6 to 18 years of age. BMI and CV risk score were significantly correlated (P < 0.0001), and both were correlated with cIMT (r = 0.14, P = 0.02 and r = 0.16, P = 0.006, respectively). Slight age-related differences in associations of cIMT with CV risk score and BMI were explained by unusual values in a few children.
These cross-sectional data in normal children show that cIMT was stable from childhood into adolescence. However, both BMI and CV risk score had small, but significant positive correlations with cIMT. Therefore, maintaining normal levels of adiposity and other risk variables may be useful in preventing early changes associated with preclinical atherosclerosis.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Age of Onset</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Child</subject><subject>Child Development - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Original</subject><subject>Risk Factors</subject><issn>1540-4196</issn><issn>1557-8518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd9LHDEQx4NUqrV99LXksQ_umdnd7CYvwvWoP0ARxD6HuWTOS93baJJT-t83iz-oMJCBfPjODB_GDkHMQCh9vKE8qwX0MwGt3mH7IGVfKQnq09S3ompBd3vsS0p_hKhrEPIz26t1C3XfNfssz1MK1mP2YeQ_KT8TjXyBMWTv-MWY_Qb5FTmP_Hbt7f1IKR3x-R0dcRzdBDofnjDZ7YCR3_h0z0_R5hAT9yVn7QcXS-DEzl0YKFkac_rKdlc4JPr2-h6w36e_bhfn1eX12cViflnZRvW5wg5ah0uFCBaExVVTK1ICSZb1USpLSE42GmynUZcS0vYEerWErilsc8BOXnIftssNuWl2xME8xHJV_GsCevPxZ_RrcxeejFS9km1bAn68BsTwuKWUzcaXE4YBRwrbZEBr3SmAbkKrF9TGkFKk1fsYEGYyZYopM5kyk6nCf_9_t3f6TU3zD6ikkVc</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Gooty, Vasu D</creator><creator>Sinaiko, Alan R</creator><creator>Ryder, Justin R</creator><creator>Dengel, Donald R</creator><creator>Jacobs, Jr, David R</creator><creator>Steinberger, Julia</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201804</creationdate><title>Association Between Carotid Intima Media Thickness, Age, and Cardiovascular Risk Factors in Children and Adolescents</title><author>Gooty, Vasu D ; Sinaiko, Alan R ; Ryder, Justin R ; Dengel, Donald R ; Jacobs, Jr, David R ; Steinberger, Julia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-a614dab8aa1c10caf328e80ae5941a58ceaed5391c69a99a905c7e19fb1633283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Age of Onset</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Child</topic><topic>Child Development - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Original</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gooty, Vasu D</creatorcontrib><creatorcontrib>Sinaiko, Alan R</creatorcontrib><creatorcontrib>Ryder, Justin R</creatorcontrib><creatorcontrib>Dengel, Donald R</creatorcontrib><creatorcontrib>Jacobs, Jr, David R</creatorcontrib><creatorcontrib>Steinberger, Julia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Metabolic syndrome and related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gooty, Vasu D</au><au>Sinaiko, Alan R</au><au>Ryder, Justin R</au><au>Dengel, Donald R</au><au>Jacobs, Jr, David R</au><au>Steinberger, Julia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Carotid Intima Media Thickness, Age, and Cardiovascular Risk Factors in Children and Adolescents</atitle><jtitle>Metabolic syndrome and related disorders</jtitle><addtitle>Metab Syndr Relat Disord</addtitle><date>2018-04</date><risdate>2018</risdate><volume>16</volume><issue>3</issue><spage>122</spage><epage>126</epage><pages>122-126</pages><issn>1540-4196</issn><eissn>1557-8518</eissn><abstract>Measures of carotid intima media thickness (cIMT) in adults are correlated with adiposity and the metabolic syndrome (MetS) and predict cardiovascular (CV) events. Relations in children are not as well studied. Our objective was to determine the relations of cIMT with body mass index (BMI) and CV risk score in children.
The study included 291 children (158 M/133 F) 6-18 years of age (140 aged 6-11/151 aged 12-18) with measurements of height, weight, waist circumference; fasting lipids, glucose, insulin, and cIMT. A CV risk cluster score was developed from sum of the z-scores of the five MetS components (waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and insulin). Partial Pearson correlation coefficients were adjusted for age, sex, and race.
There was no significant age difference in cIMT from 6 to 18 years of age. BMI and CV risk score were significantly correlated (P < 0.0001), and both were correlated with cIMT (r = 0.14, P = 0.02 and r = 0.16, P = 0.006, respectively). Slight age-related differences in associations of cIMT with CV risk score and BMI were explained by unusual values in a few children.
These cross-sectional data in normal children show that cIMT was stable from childhood into adolescence. However, both BMI and CV risk score had small, but significant positive correlations with cIMT. Therefore, maintaining normal levels of adiposity and other risk variables may be useful in preventing early changes associated with preclinical atherosclerosis.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>29412763</pmid><doi>10.1089/met.2017.0149</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Age Factors Age of Onset Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Carotid Intima-Media Thickness Child Child Development - physiology Cross-Sectional Studies Female Humans Longitudinal Studies Male Original Risk Factors |
| title | Association Between Carotid Intima Media Thickness, Age, and Cardiovascular Risk Factors in Children and Adolescents |
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