Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity

Recently, nongenetic animal models to study the onset and development of Alzheimer’s disease (AD) have appeared, such as the intrahippocampal infusion of peptides present in Alzheimer amyloid plaques [i.e., amyloid-β (Aβ)]. Nonpharmacological approaches to AD treatment also have been advanced recent...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-03, Vol.115 (10), p.E2403-E2409
Hauptverfasser:	Lima, Mariza G. Prado, Schimidt, Helen L., Garcia, Alexandre, Daré, Letícia R., Carpes, Felipe P., Izquierdo, Ivan, Mello-Carpes, Pâmela B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Alzheimer Disease - metabolism Alzheimer Disease - psychology Alzheimer Disease - therapy Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - toxicity Animal models Animals Antioxidants Biological Sciences Damage prevention Enrichment Environment Exercise Exercise Therapy Hippocampus Hippocampus - metabolism Humans Learning Lipid Peroxidation Long term memory Male Maze Learning Memory Memory Disorders - metabolism Memory Disorders - psychology Memory Disorders - therapy Model testing Neurodegenerative diseases Neuroprotection Neurotoxicity Object recognition Oxidative Stress Pattern recognition Peptides Peroxidation Physical exercise PNAS Plus Rats Rats, Wistar Reactive oxygen species Reactive Oxygen Species - metabolism Senile plaques Short term memory Social Environment Social interactions Thiobarbituric acid
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