Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120

The HIV-1 envelope protein (Env) of early-replicating viruses encodes several distinct transmission signatures. One such signature involves a reduced number of potential N-linked glycosylation sites (PNGs). This transmission signature underscores the importance of posttranslational modifications in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-03, Vol.115 (10), p.2443-2448
Hauptverfasser:	Yolitz, Jason, Schwing, Catherine, Chang, Julia, Van Ryk, Donald, Nawaz, Fatima, Wei, Danlan, Cicala, Claudia, Arthos, James, Fauci, Anthony S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino acids Antibodies, Monoclonal - metabolism Antigenicity Biological Sciences CD4 antigen DC-SIGN protein Dendritic Cells Disease transmission Fitness Glycan Glycoprotein gp120 Glycosylation HIV HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp120 - metabolism HIV-1 - immunology Human immunodeficiency virus Monoclonal antibodies Mucosa Peptides Protein Sorting Signals - genetics Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism Replication Surface plasmon resonance Viral envelope proteins
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