DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice

Cell-cycle dysfunction and faulty DNA repair are closely intertwined pathobiological processes that may contribute to several neurodegenerative disorders. CDKN1A interacting zinc finger protein 1 (CIZ1) plays a critical role in DNA replication and cell-cycle progression at the G1/S checkpoint. Germl...

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Veröffentlicht in:	Neurobiology of aging 2018-02, Vol.62, p.180-190
Hauptverfasser:	Khan, Mohammad Moshahid, Xiao, Jianfeng, Patel, Damini, LeDoux, Mark S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - pathology Animals Apoptosis Brain - metabolism Cell cycle Cell Cycle - genetics Cells, Cultured CIZ1 Cognition Cognitive Aging DNA Damage DNA Repair Female Fibroblasts - pathology Genes, cdc - genetics Male Mice Molecular Targeted Therapy Neurodegenerative Diseases - etiology Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology NF-kappa B - metabolism Nuclear Proteins - deficiency Nuclear Proteins - physiology Oxidative Stress Phenotype
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