Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice
Hydroquinone (HQ, 1,4-benzenediol) is a hydroxylated benzene metabolite with various biological activities, including anti-oxidative, neuroprotective, immunomodulatory, and anti-inflammatory functions. However, the anti-cancer activity of HQ is not well understood. In this study, the in vitro and in...
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| Veröffentlicht in: | International journal of molecular sciences 2018-03, Vol.19 (3), p.903 |
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| creator | Byeon, Se Eun Yi, Young-Su Lee, Jongsung Yang, Woo Seok Kim, Ji Hye Kim, Jooyoung Hong, Suntaek Kim, Jong-Hoon Cho, Jae Youl |
| description | Hydroquinone (HQ, 1,4-benzenediol) is a hydroxylated benzene metabolite with various biological activities, including anti-oxidative, neuroprotective, immunomodulatory, and anti-inflammatory functions. However, the anti-cancer activity of HQ is not well understood. In this study, the in vitro and in vivo anti-cancer activity of HQ was investigated in various cancer cells and tumor-bearing mouse models. HQ significantly induced the death of A431, SYF, B16F10, and MDA-MB-231 cells and also showed a synergistic effect on A431 cell death with other anti-cancer agents, such as adenosine-2',3'-dialdehyde and buthionine sulfoximine. In addition, HQ suppressed angiogenesis in fertilized chicken embryos. Moreover, HQ prevented lung metastasis of melanoma cells in mice in a dose-dependent manner without toxicity and adverse effects. HQ (10 mg/kg) also suppressed the generation of colon and reduced the thickness of colon tissues in azoxymethane/dextran sodium sulfate-injected mice. This study strongly suggests that HQ possesses in vitro and in vivo anti-cancer activity and provides evidence that HQ could be developed as an effective and safe anti-cancer drug. |
| doi_str_mv | 10.3390/ijms19030903 |
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However, the anti-cancer activity of HQ is not well understood. In this study, the in vitro and in vivo anti-cancer activity of HQ was investigated in various cancer cells and tumor-bearing mouse models. HQ significantly induced the death of A431, SYF, B16F10, and MDA-MB-231 cells and also showed a synergistic effect on A431 cell death with other anti-cancer agents, such as adenosine-2',3'-dialdehyde and buthionine sulfoximine. In addition, HQ suppressed angiogenesis in fertilized chicken embryos. Moreover, HQ prevented lung metastasis of melanoma cells in mice in a dose-dependent manner without toxicity and adverse effects. HQ (10 mg/kg) also suppressed the generation of colon and reduced the thickness of colon tissues in azoxymethane/dextran sodium sulfate-injected mice. This study strongly suggests that HQ possesses in vitro and in vivo anti-cancer activity and provides evidence that HQ could be developed as an effective and safe anti-cancer drug.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms19030903</identifier><identifier>PMID: 29562668</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenosine ; Angiogenesis ; Animal models ; Azoxymethane ; Benzene ; Biocompatibility ; Buthionine sulfoximine ; Cancer ; Cell death ; Colon ; Dextran ; Embryos ; Hydroquinone ; Immunomodulation ; In vivo methods and tests ; Inflammation ; Lung cancer ; Melanoma ; Metastases ; Neuroprotection ; Reagents ; Synergistic effect ; Toxicity</subject><ispartof>International journal of molecular sciences, 2018-03, Vol.19 (3), p.903</ispartof><rights>2018. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-1db09977c2ea0b4a3a73f395119858610a3fecfe8164ed91ea03623eea5ab4303</citedby><cites>FETCH-LOGICAL-c412t-1db09977c2ea0b4a3a73f395119858610a3fecfe8164ed91ea03623eea5ab4303</cites><orcidid>0000-0001-5062-9868 ; 0000-0001-8141-9927 ; 0000-0002-5073-2619 ; 0000-0002-7166-3659</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877764/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877764/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29562668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Byeon, Se Eun</creatorcontrib><creatorcontrib>Yi, Young-Su</creatorcontrib><creatorcontrib>Lee, Jongsung</creatorcontrib><creatorcontrib>Yang, Woo Seok</creatorcontrib><creatorcontrib>Kim, Ji Hye</creatorcontrib><creatorcontrib>Kim, Jooyoung</creatorcontrib><creatorcontrib>Hong, Suntaek</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><creatorcontrib>Cho, Jae Youl</creatorcontrib><title>Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Hydroquinone (HQ, 1,4-benzenediol) is a hydroxylated benzene metabolite with various biological activities, including anti-oxidative, neuroprotective, immunomodulatory, and anti-inflammatory functions. However, the anti-cancer activity of HQ is not well understood. In this study, the in vitro and in vivo anti-cancer activity of HQ was investigated in various cancer cells and tumor-bearing mouse models. HQ significantly induced the death of A431, SYF, B16F10, and MDA-MB-231 cells and also showed a synergistic effect on A431 cell death with other anti-cancer agents, such as adenosine-2',3'-dialdehyde and buthionine sulfoximine. In addition, HQ suppressed angiogenesis in fertilized chicken embryos. Moreover, HQ prevented lung metastasis of melanoma cells in mice in a dose-dependent manner without toxicity and adverse effects. HQ (10 mg/kg) also suppressed the generation of colon and reduced the thickness of colon tissues in azoxymethane/dextran sodium sulfate-injected mice. This study strongly suggests that HQ possesses in vitro and in vivo anti-cancer activity and provides evidence that HQ could be developed as an effective and safe anti-cancer drug.</description><subject>Adenosine</subject><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Azoxymethane</subject><subject>Benzene</subject><subject>Biocompatibility</subject><subject>Buthionine sulfoximine</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Colon</subject><subject>Dextran</subject><subject>Embryos</subject><subject>Hydroquinone</subject><subject>Immunomodulation</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Lung cancer</subject><subject>Melanoma</subject><subject>Metastases</subject><subject>Neuroprotection</subject><subject>Reagents</subject><subject>Synergistic effect</subject><subject>Toxicity</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1LwzAYxoMobk5vnqXgxYPVfDRNcxFGmW4w8aLiLaRp6jK6ZCbtcP-9nZsyhYTkTX55eJ88AJwjeEMIh7dmvgiIQwK7eQD6KME4hjBlh3v7HjgJYQ4hJpjyY9DDnKY4TbM-eBuvS-8-WmOd1dHoc2YK04RoYqNX03gXSVtui5WLhrYxcS6t0j4aqsasTLOOjI12R7mu6_D94NEofQqOKlkHfbZbB-DlfvScj-Pp08MkH05jlSDcxKgsIOeMKawlLBJJJCMV4RQhntEsRVCSSqtKZyhNdMlRR5EUE60llUVCIBmAu63usi0WulTaNl7WYunNQvq1cNKIvzfWzMS7WwmaMcbSpBO42gls_kGHRixMUJ0XabVrg8AQMUgp5qRDL_-hc9d629kTGMEsoYh0YwCut5TyLgSvq99mEBSbyMR-ZB1-sW_gF_7JiHwBcb6RWg</recordid><startdate>20180319</startdate><enddate>20180319</enddate><creator>Byeon, Se Eun</creator><creator>Yi, Young-Su</creator><creator>Lee, Jongsung</creator><creator>Yang, Woo Seok</creator><creator>Kim, Ji Hye</creator><creator>Kim, Jooyoung</creator><creator>Hong, Suntaek</creator><creator>Kim, Jong-Hoon</creator><creator>Cho, Jae Youl</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5062-9868</orcidid><orcidid>https://orcid.org/0000-0001-8141-9927</orcidid><orcidid>https://orcid.org/0000-0002-5073-2619</orcidid><orcidid>https://orcid.org/0000-0002-7166-3659</orcidid></search><sort><creationdate>20180319</creationdate><title>Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice</title><author>Byeon, Se Eun ; 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However, the anti-cancer activity of HQ is not well understood. In this study, the in vitro and in vivo anti-cancer activity of HQ was investigated in various cancer cells and tumor-bearing mouse models. HQ significantly induced the death of A431, SYF, B16F10, and MDA-MB-231 cells and also showed a synergistic effect on A431 cell death with other anti-cancer agents, such as adenosine-2',3'-dialdehyde and buthionine sulfoximine. In addition, HQ suppressed angiogenesis in fertilized chicken embryos. Moreover, HQ prevented lung metastasis of melanoma cells in mice in a dose-dependent manner without toxicity and adverse effects. HQ (10 mg/kg) also suppressed the generation of colon and reduced the thickness of colon tissues in azoxymethane/dextran sodium sulfate-injected mice. This study strongly suggests that HQ possesses in vitro and in vivo anti-cancer activity and provides evidence that HQ could be developed as an effective and safe anti-cancer drug.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29562668</pmid><doi>10.3390/ijms19030903</doi><orcidid>https://orcid.org/0000-0001-5062-9868</orcidid><orcidid>https://orcid.org/0000-0001-8141-9927</orcidid><orcidid>https://orcid.org/0000-0002-5073-2619</orcidid><orcidid>https://orcid.org/0000-0002-7166-3659</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine Angiogenesis Animal models Azoxymethane Benzene Biocompatibility Buthionine sulfoximine Cancer Cell death Colon Dextran Embryos Hydroquinone Immunomodulation In vivo methods and tests Inflammation Lung cancer Melanoma Metastases Neuroprotection Reagents Synergistic effect Toxicity |
| title | Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice |
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