Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn gr...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2018-03, Vol.19 (3), p.833 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 833 |
| container_title | International journal of molecular sciences |
| container_volume | 19 |
| creator | Zou, Shenglong Kumar, Ujendra |
| description | The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
(marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids. |
| doi_str_mv | 10.3390/ijms19030833 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5877694</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2013784949</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-2ea4ad7427d4dff5323434fec00236eef2a7e38d93ed1e3a736b362a440eca943</originalsourceid><addsrcrecordid>eNpdkctLMzEUxYMoPqo71zLgxoXVTG46mbj44KP4AlHwsQ5pcqemzCQ1mRH87x3bKtVVLuR3DufeQ8hhTs8AJD13syblkgItATbIbs4ZG1JaiM21eYfspTSjlAEbyW2yw-So14pyl8zG2ns9cT44mz2iwXkbYsq0t1n7itmlt8GsEU8fqcXmIntyU69r56cL8qrzpnXBZ84vVGP0bdR1do_xPXRppdonW5WuEx6s3gF5ubp8Ht8M7x6ub8f_74aGi7IdMtRcW8GZsNxW1QgYcOAVmq_4BWLFtEAorQS0OYIWUEygYJpzikZLDgPyb-k77yYNWrMMo-bRNTp-qKCd-v3j3auahnc1KoUoFgYnK4MY3jpMrWpcMljX2mO_jmI0B1FyyWWPHv9BZ6GL_Wl6Kqcl55L1lx6Q0yVlYkgpYvUTJqfqq0S1XmKPH60v8AN_twaf8xKZ6g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2108449253</pqid></control><display><type>article</type><title>Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Zou, Shenglong ; Kumar, Ujendra</creator><creatorcontrib>Zou, Shenglong ; Kumar, Ujendra</creatorcontrib><description>The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
(marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms19030833</identifier><identifier>PMID: 29533978</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Biological effects ; Cannabinoid CB1 receptors ; Cannabinoid Receptor Agonists - pharmacology ; Cannabis ; Central nervous system ; Central Nervous System - drug effects ; Central Nervous System - metabolism ; Endocannabinoid system ; Endocannabinoids - metabolism ; G protein-coupled receptors ; Humans ; Marijuana ; Nervous system ; Proteins ; Receptor mechanisms ; Receptors, Cannabinoid - genetics ; Receptors, Cannabinoid - metabolism ; Review ; Signal Transduction</subject><ispartof>International journal of molecular sciences, 2018-03, Vol.19 (3), p.833</ispartof><rights>2018. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-2ea4ad7427d4dff5323434fec00236eef2a7e38d93ed1e3a736b362a440eca943</citedby><cites>FETCH-LOGICAL-c478t-2ea4ad7427d4dff5323434fec00236eef2a7e38d93ed1e3a736b362a440eca943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29533978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zou, Shenglong</creatorcontrib><creatorcontrib>Kumar, Ujendra</creatorcontrib><title>Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
(marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.</description><subject>Animals</subject><subject>Biological effects</subject><subject>Cannabinoid CB1 receptors</subject><subject>Cannabinoid Receptor Agonists - pharmacology</subject><subject>Cannabis</subject><subject>Central nervous system</subject><subject>Central Nervous System - drug effects</subject><subject>Central Nervous System - metabolism</subject><subject>Endocannabinoid system</subject><subject>Endocannabinoids - metabolism</subject><subject>G protein-coupled receptors</subject><subject>Humans</subject><subject>Marijuana</subject><subject>Nervous system</subject><subject>Proteins</subject><subject>Receptor mechanisms</subject><subject>Receptors, Cannabinoid - genetics</subject><subject>Receptors, Cannabinoid - metabolism</subject><subject>Review</subject><subject>Signal Transduction</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctLMzEUxYMoPqo71zLgxoXVTG46mbj44KP4AlHwsQ5pcqemzCQ1mRH87x3bKtVVLuR3DufeQ8hhTs8AJD13syblkgItATbIbs4ZG1JaiM21eYfspTSjlAEbyW2yw-So14pyl8zG2ns9cT44mz2iwXkbYsq0t1n7itmlt8GsEU8fqcXmIntyU69r56cL8qrzpnXBZ84vVGP0bdR1do_xPXRppdonW5WuEx6s3gF5ubp8Ht8M7x6ub8f_74aGi7IdMtRcW8GZsNxW1QgYcOAVmq_4BWLFtEAorQS0OYIWUEygYJpzikZLDgPyb-k77yYNWrMMo-bRNTp-qKCd-v3j3auahnc1KoUoFgYnK4MY3jpMrWpcMljX2mO_jmI0B1FyyWWPHv9BZ6GL_Wl6Kqcl55L1lx6Q0yVlYkgpYvUTJqfqq0S1XmKPH60v8AN_twaf8xKZ6g</recordid><startdate>20180313</startdate><enddate>20180313</enddate><creator>Zou, Shenglong</creator><creator>Kumar, Ujendra</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180313</creationdate><title>Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System</title><author>Zou, Shenglong ; Kumar, Ujendra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-2ea4ad7427d4dff5323434fec00236eef2a7e38d93ed1e3a736b362a440eca943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Biological effects</topic><topic>Cannabinoid CB1 receptors</topic><topic>Cannabinoid Receptor Agonists - pharmacology</topic><topic>Cannabis</topic><topic>Central nervous system</topic><topic>Central Nervous System - drug effects</topic><topic>Central Nervous System - metabolism</topic><topic>Endocannabinoid system</topic><topic>Endocannabinoids - metabolism</topic><topic>G protein-coupled receptors</topic><topic>Humans</topic><topic>Marijuana</topic><topic>Nervous system</topic><topic>Proteins</topic><topic>Receptor mechanisms</topic><topic>Receptors, Cannabinoid - genetics</topic><topic>Receptors, Cannabinoid - metabolism</topic><topic>Review</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zou, Shenglong</creatorcontrib><creatorcontrib>Kumar, Ujendra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zou, Shenglong</au><au>Kumar, Ujendra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2018-03-13</date><risdate>2018</risdate><volume>19</volume><issue>3</issue><spage>833</spage><pages>833-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
(marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29533978</pmid><doi>10.3390/ijms19030833</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2018-03, Vol.19 (3), p.833 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5877694 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Animals Biological effects Cannabinoid CB1 receptors Cannabinoid Receptor Agonists - pharmacology Cannabis Central nervous system Central Nervous System - drug effects Central Nervous System - metabolism Endocannabinoid system Endocannabinoids - metabolism G protein-coupled receptors Humans Marijuana Nervous system Proteins Receptor mechanisms Receptors, Cannabinoid - genetics Receptors, Cannabinoid - metabolism Review Signal Transduction |
| title | Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T13%3A39%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cannabinoid%20Receptors%20and%20the%20Endocannabinoid%20System:%20Signaling%20and%20Function%20in%20the%20Central%20Nervous%20System&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Zou,%20Shenglong&rft.date=2018-03-13&rft.volume=19&rft.issue=3&rft.spage=833&rft.pages=833-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms19030833&rft_dat=%3Cproquest_pubme%3E2013784949%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2108449253&rft_id=info:pmid/29533978&rfr_iscdi=true |