Graphene Oxide-Silver Nanocomposite Enhances Cytotoxic and Apoptotic Potential of Salinomycin in Human Ovarian Cancer Stem Cells (OvCSCs): A Novel Approach for Cancer Therapy

The use of graphene to target and eliminate cancer stem cells (CSCs) is an alternative approach to conventional chemotherapy. We show the biomolecule-mediated synthesis of reduced graphene oxide-silver nanoparticle nanocomposites (rGO-Ag) using R-phycoerythrin (RPE); the resulting RPE-rGO-Ag was eva...

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Veröffentlicht in:	International journal of molecular sciences 2018-03, Vol.19 (3), p.710
Hauptverfasser:	Choi, Yun-Jung, Gurunathan, Sangiliyandi, Kim, Jin-Hoi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biomarkers Cancer therapies Cell Line, Tumor Cell Survival - drug effects Chemotherapy Cytotoxicity Dose-Response Relationship, Drug Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Graphene Graphite - chemistry Humans Immunophenotyping L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Low concentrations Membrane potential Membrane Potential, Mitochondrial - drug effects Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Mitochondria Models, Biological Nanocomposites Nanoparticles Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Ovarian cancer Ovarian Neoplasms Oxides - chemistry Pyrans - chemistry Pyrans - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism Salinomycin Silver Silver - chemistry Stem cells Tumor cells Tumor Stem Cell Assay Tumors
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