Baclofen and gastroesophageal reflux disease: seeing the forest through the trees

Baclofen and gastroesophageal reflux disease: seeing the forest through the trees

Baclofen has been shown to decrease reflux events and increase lower esophageal sphincter pressure, yet has never established a clear role in the treatment of gastroesophageal reflux disease (GERD). Lei and colleagues have shown in a recent elegant study that baclofen reduces the frequency and initi...

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Veröffentlicht in:Clinical and translational gastroenterology 2018-03, Vol.9 (3), p.137-3
Hauptverfasser: Clarke, John O, Fernandez-Becker, Nielsen Q, Regalia, Kirsten A, Triadafilopoulos, George
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Esophagus
Gastroesophageal reflux
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container_end_page 3
container_issue 3
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container_title Clinical and translational gastroenterology
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creator Clarke, John O
Fernandez-Becker, Nielsen Q
Regalia, Kirsten A
Triadafilopoulos, George
description Baclofen has been shown to decrease reflux events and increase lower esophageal sphincter pressure, yet has never established a clear role in the treatment of gastroesophageal reflux disease (GERD). Lei and colleagues have shown in a recent elegant study that baclofen reduces the frequency and initiation of secondary peristalsis and heightens esophageal sensitivity to capsaicin-mediated stimulation. These findings may help explain both the benefit of baclofen in conditions such as rumination and supragastric belching, as well as the apparent lack of benefit of baclofen and other GABA agonists in long-term treatment of GERD.
doi_str_mv 10.1038/s41424-018-0010-y
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subjects Esophagus
Gastroesophageal reflux
title Baclofen and gastroesophageal reflux disease: seeing the forest through the trees
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