Alu-Mediated Inactivation of the Human CMP-N-Acetylneuraminic Acid Hydroxylase Gene

Inactivation of the CMP-N-acetylneuraminic acid hydroxylase gene has provided an example of human-specific genomic mutation that results in a widespread biochemical difference between human and nonhuman primates. We have found that, although a region containing a 92-bp exon and an AluSq element in t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-09, Vol.98 (20), p.11399-11404
Hauptverfasser:	Hayakawa, Toshiyuki, Satta, Yoko, Gagneux, Pascal, Varki, Ajit, Takahata, Naoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alu Elements - genetics Animals Base Sequence Biological Sciences CMP-N-acetylneuraminic acid hydroxylase gene Complementary DNA DNA Evolution Evolution, Molecular Exons Genetics Genomics Gorilla gorilla - genetics Humans Hylobates - genetics Macaca mulatta Mixed Function Oxygenases - genetics Molecular Sequence Data Mutation Pan troglodytes - genetics Phylogeny Polymerase Chain Reaction Pongo pygmaeus - genetics Primates Primates - genetics RNA Sequence Deletion Sequencing Studies transposon AluSq transposon AluY
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