Decreased ATP production and myocardial contractile reserve in metabolic heart disease

Metabolic syndrome is a cluster of obesity-related metabolic abnormalities that lead to metabolic heart disease (MHD) with left ventricular pump dysfunction. Although MHD is thought to be associated with myocardial energetic deficiency, two key questions have not been answered. First, it is not know...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2018-03, Vol.116, p.106-114
Hauptverfasser:	Luptak, Ivan, Sverdlov, Aaron L., Panagia, Marcello, Qin, Fuzhong, Pimentel, David R., Croteau, Dominique, Siwik, Deborah A., Ingwall, Joanne S., Bachschmid, Markus M., Balschi, James A., Colucci, Wilson S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Body Weight Contractile function Creatine Kinase - metabolism Diastole Diet, High-Fat Dietary Sucrose Energy Metabolism Heart Diseases - metabolism Heart Diseases - physiopathology Heart failure Hydrolysis Magnetic Resonance Spectroscopy Male Metabolic syndrome Metabolism Mice, Inbred C57BL Myocardial Contraction Obesity Organ Size Perfusion
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