PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells

Prostaglandin E (PGE ) contributes to tumor progression by promoting cancer cell growth, invasion and by creating a favorable pro-tumor microenvironment. PGE has been reported to transactivate and internalize into the nucleus receptor tyrosine kinases such as Epidermal growth factor receptor (EGFR),...

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Veröffentlicht in:	Oncotarget 2018-03, Vol.9 (19), p.14939-14958
Hauptverfasser:	Bazzani, Lorenzo, Donnini, Sandra, Giachetti, Antonio, Christofori, Gerhard, Ziche, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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