Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China
The global spread of carbapenem-resistant (CRE) is one of the most severe threats to human health in a clinical setting. The recent emergence of plasmid-mediated colistin resistance gene among CRE strains greatly compromises the use of colistin as a last resort for the treatment of infections caused...
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| Veröffentlicht in: | Journal of clinical microbiology 2018-04, Vol.56 (4) |
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| container_title | Journal of clinical microbiology |
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| creator | Li, Yi Sun, Qiao-Ling Shen, Yingbo Zhang, Yangjunna Yang, Jun-Wen Shu, Ling-Bin Zhou, Hong-Wei Wang, Yang Wang, Bing Zhang, Rong Wang, Shaolin Shen, Zhangqi |
| description | The global spread of carbapenem-resistant
(CRE) is one of the most severe threats to human health in a clinical setting. The recent emergence of plasmid-mediated colistin resistance gene
among CRE strains greatly compromises the use of colistin as a last resort for the treatment of infections caused by CRE. This study aimed to understand the current epidemiological trends and characteristics of CRE from a large hospital in Henan, the most populous province in China. From 2014 to 2016, a total of 7,249
isolates were collected from clinical samples, among which 18.1% (1,311/7,249) were carbapenem resistant. Carbapenem-resistant
and carbapenem-resistant
were the two most common CRE species, with
carbapenemases (KPC) and New Delhi metallo-β-lactamases (NDM), respectively, responsible for the carbapenem resistance of the two species. Notably, >57.0% (
= 589) of the
isolates from the intensive care unit were carbapenem resistant. Furthermore,
and
were found to coexist in one
isolate, which exhibited resistance to almost all tested antibiotics. Overall, we observed a significant increase in the prevalence of CRE isolates during the study period and suggest that carbapenems may no longer be considered to be an effective treatment for infections caused by
in the studied hospital. |
| doi_str_mv | 10.1128/JCM.01932-17 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5869811</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1993383104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-2e5ef94fcf594265ece3ffa92a738971a25855fcbbef1b336338ab3d724fdbb33</originalsourceid><addsrcrecordid>eNpVUU1v1DAQtRCILgs3zsjHIjXFjuMkviChaOkWFYFWIHGzJs64NUrs1M5W4u_wS_HSdgWnJ4_fx9iPkNecnXNetu8-dZ_PGVeiLHjzhKw4U21R1-zHU7JiTMmCc9GckBcp_WSMV5WUz8lJqURbl7Vckd87mN1AL72JCAmp8_RrxDsY0RukwdIOYg8zepyKHSaXFvAL3fgFY-jBZHBgEJCedrvNWwp-oJsJ4_VRHsasya6P4jy-yG50MrHgh7isOwDQbUizW2A8nLbowZ_R7sZ5eEmeWRgTvnrANfn-cfOt2xZXXy4uuw9XhRFttRQlSrSqssZKVeW3oUFhLagSGtGqhkMpWymt6Xu0vBeiFqKFXgxNWdmhz4M1eX_vO-_7CQeDfokw6jm6CeIvHcDp_2-8u9HX4U7LtlZt_uY1OX0wiOF2j2nRk0sGxxE8hn3SXKmcKTirMvXsnmpiSCmiPcZwpg-16lyr_lur5k2mv_l3tSP5sUfxB7STn4I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1993383104</pqid></control><display><type>article</type><title>Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China</title><source>American Society for Microbiology</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Li, Yi ; Sun, Qiao-Ling ; Shen, Yingbo ; Zhang, Yangjunna ; Yang, Jun-Wen ; Shu, Ling-Bin ; Zhou, Hong-Wei ; Wang, Yang ; Wang, Bing ; Zhang, Rong ; Wang, Shaolin ; Shen, Zhangqi</creator><contributor>Onderdonk, Andrew B.</contributor><creatorcontrib>Li, Yi ; Sun, Qiao-Ling ; Shen, Yingbo ; Zhang, Yangjunna ; Yang, Jun-Wen ; Shu, Ling-Bin ; Zhou, Hong-Wei ; Wang, Yang ; Wang, Bing ; Zhang, Rong ; Wang, Shaolin ; Shen, Zhangqi ; Onderdonk, Andrew B.</creatorcontrib><description>The global spread of carbapenem-resistant
(CRE) is one of the most severe threats to human health in a clinical setting. The recent emergence of plasmid-mediated colistin resistance gene
among CRE strains greatly compromises the use of colistin as a last resort for the treatment of infections caused by CRE. This study aimed to understand the current epidemiological trends and characteristics of CRE from a large hospital in Henan, the most populous province in China. From 2014 to 2016, a total of 7,249
isolates were collected from clinical samples, among which 18.1% (1,311/7,249) were carbapenem resistant. Carbapenem-resistant
and carbapenem-resistant
were the two most common CRE species, with
carbapenemases (KPC) and New Delhi metallo-β-lactamases (NDM), respectively, responsible for the carbapenem resistance of the two species. Notably, >57.0% (
= 589) of the
isolates from the intensive care unit were carbapenem resistant. Furthermore,
and
were found to coexist in one
isolate, which exhibited resistance to almost all tested antibiotics. Overall, we observed a significant increase in the prevalence of CRE isolates during the study period and suggest that carbapenems may no longer be considered to be an effective treatment for infections caused by
in the studied hospital.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/JCM.01932-17</identifier><identifier>PMID: 29386265</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Anti-Bacterial Agents - pharmacology ; beta-Lactamases - genetics ; Carbapenem-Resistant Enterobacteriaceae - drug effects ; Carbapenem-Resistant Enterobacteriaceae - genetics ; Carbapenems - pharmacology ; China - epidemiology ; Colistin - pharmacology ; Drug Resistance, Multiple, Bacterial - genetics ; Enterobacteriaceae Infections - epidemiology ; Epidemiology ; Escherichia coli - drug effects ; Escherichia coli - genetics ; Escherichia coli Proteins - genetics ; Hospitals ; Humans ; Intensive Care Units ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - genetics ; Microbial Sensitivity Tests ; Prevalence</subject><ispartof>Journal of clinical microbiology, 2018-04, Vol.56 (4)</ispartof><rights>Copyright © 2018 American Society for Microbiology.</rights><rights>Copyright © 2018 American Society for Microbiology. 2018 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-2e5ef94fcf594265ece3ffa92a738971a25855fcbbef1b336338ab3d724fdbb33</citedby><cites>FETCH-LOGICAL-c384t-2e5ef94fcf594265ece3ffa92a738971a25855fcbbef1b336338ab3d724fdbb33</cites><orcidid>0000-0003-0866-4584</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869811/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869811/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3174,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29386265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Onderdonk, Andrew B.</contributor><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Sun, Qiao-Ling</creatorcontrib><creatorcontrib>Shen, Yingbo</creatorcontrib><creatorcontrib>Zhang, Yangjunna</creatorcontrib><creatorcontrib>Yang, Jun-Wen</creatorcontrib><creatorcontrib>Shu, Ling-Bin</creatorcontrib><creatorcontrib>Zhou, Hong-Wei</creatorcontrib><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Wang, Bing</creatorcontrib><creatorcontrib>Zhang, Rong</creatorcontrib><creatorcontrib>Wang, Shaolin</creatorcontrib><creatorcontrib>Shen, Zhangqi</creatorcontrib><title>Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China</title><title>Journal of clinical microbiology</title><addtitle>J Clin Microbiol</addtitle><description>The global spread of carbapenem-resistant
(CRE) is one of the most severe threats to human health in a clinical setting. The recent emergence of plasmid-mediated colistin resistance gene
among CRE strains greatly compromises the use of colistin as a last resort for the treatment of infections caused by CRE. This study aimed to understand the current epidemiological trends and characteristics of CRE from a large hospital in Henan, the most populous province in China. From 2014 to 2016, a total of 7,249
isolates were collected from clinical samples, among which 18.1% (1,311/7,249) were carbapenem resistant. Carbapenem-resistant
and carbapenem-resistant
were the two most common CRE species, with
carbapenemases (KPC) and New Delhi metallo-β-lactamases (NDM), respectively, responsible for the carbapenem resistance of the two species. Notably, >57.0% (
= 589) of the
isolates from the intensive care unit were carbapenem resistant. Furthermore,
and
were found to coexist in one
isolate, which exhibited resistance to almost all tested antibiotics. Overall, we observed a significant increase in the prevalence of CRE isolates during the study period and suggest that carbapenems may no longer be considered to be an effective treatment for infections caused by
in the studied hospital.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>beta-Lactamases - genetics</subject><subject>Carbapenem-Resistant Enterobacteriaceae - drug effects</subject><subject>Carbapenem-Resistant Enterobacteriaceae - genetics</subject><subject>Carbapenems - pharmacology</subject><subject>China - epidemiology</subject><subject>Colistin - pharmacology</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Enterobacteriaceae Infections - epidemiology</subject><subject>Epidemiology</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli Proteins - genetics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Microbial Sensitivity Tests</subject><subject>Prevalence</subject><issn>0095-1137</issn><issn>1098-660X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1v1DAQtRCILgs3zsjHIjXFjuMkviChaOkWFYFWIHGzJs64NUrs1M5W4u_wS_HSdgWnJ4_fx9iPkNecnXNetu8-dZ_PGVeiLHjzhKw4U21R1-zHU7JiTMmCc9GckBcp_WSMV5WUz8lJqURbl7Vckd87mN1AL72JCAmp8_RrxDsY0RukwdIOYg8zepyKHSaXFvAL3fgFY-jBZHBgEJCedrvNWwp-oJsJ4_VRHsasya6P4jy-yG50MrHgh7isOwDQbUizW2A8nLbowZ_R7sZ5eEmeWRgTvnrANfn-cfOt2xZXXy4uuw9XhRFttRQlSrSqssZKVeW3oUFhLagSGtGqhkMpWymt6Xu0vBeiFqKFXgxNWdmhz4M1eX_vO-_7CQeDfokw6jm6CeIvHcDp_2-8u9HX4U7LtlZt_uY1OX0wiOF2j2nRk0sGxxE8hn3SXKmcKTirMvXsnmpiSCmiPcZwpg-16lyr_lur5k2mv_l3tSP5sUfxB7STn4I</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Li, Yi</creator><creator>Sun, Qiao-Ling</creator><creator>Shen, Yingbo</creator><creator>Zhang, Yangjunna</creator><creator>Yang, Jun-Wen</creator><creator>Shu, Ling-Bin</creator><creator>Zhou, Hong-Wei</creator><creator>Wang, Yang</creator><creator>Wang, Bing</creator><creator>Zhang, Rong</creator><creator>Wang, Shaolin</creator><creator>Shen, Zhangqi</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0866-4584</orcidid></search><sort><creationdate>20180401</creationdate><title>Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China</title><author>Li, Yi ; Sun, Qiao-Ling ; Shen, Yingbo ; Zhang, Yangjunna ; Yang, Jun-Wen ; Shu, Ling-Bin ; Zhou, Hong-Wei ; Wang, Yang ; Wang, Bing ; Zhang, Rong ; Wang, Shaolin ; Shen, Zhangqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-2e5ef94fcf594265ece3ffa92a738971a25855fcbbef1b336338ab3d724fdbb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>beta-Lactamases - genetics</topic><topic>Carbapenem-Resistant Enterobacteriaceae - drug effects</topic><topic>Carbapenem-Resistant Enterobacteriaceae - genetics</topic><topic>Carbapenems - pharmacology</topic><topic>China - epidemiology</topic><topic>Colistin - pharmacology</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Enterobacteriaceae Infections - epidemiology</topic><topic>Epidemiology</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli Proteins - genetics</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Microbial Sensitivity Tests</topic><topic>Prevalence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Sun, Qiao-Ling</creatorcontrib><creatorcontrib>Shen, Yingbo</creatorcontrib><creatorcontrib>Zhang, Yangjunna</creatorcontrib><creatorcontrib>Yang, Jun-Wen</creatorcontrib><creatorcontrib>Shu, Ling-Bin</creatorcontrib><creatorcontrib>Zhou, Hong-Wei</creatorcontrib><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Wang, Bing</creatorcontrib><creatorcontrib>Zhang, Rong</creatorcontrib><creatorcontrib>Wang, Shaolin</creatorcontrib><creatorcontrib>Shen, Zhangqi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yi</au><au>Sun, Qiao-Ling</au><au>Shen, Yingbo</au><au>Zhang, Yangjunna</au><au>Yang, Jun-Wen</au><au>Shu, Ling-Bin</au><au>Zhou, Hong-Wei</au><au>Wang, Yang</au><au>Wang, Bing</au><au>Zhang, Rong</au><au>Wang, Shaolin</au><au>Shen, Zhangqi</au><au>Onderdonk, Andrew B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China</atitle><jtitle>Journal of clinical microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>56</volume><issue>4</issue><issn>0095-1137</issn><eissn>1098-660X</eissn><abstract>The global spread of carbapenem-resistant
(CRE) is one of the most severe threats to human health in a clinical setting. The recent emergence of plasmid-mediated colistin resistance gene
among CRE strains greatly compromises the use of colistin as a last resort for the treatment of infections caused by CRE. This study aimed to understand the current epidemiological trends and characteristics of CRE from a large hospital in Henan, the most populous province in China. From 2014 to 2016, a total of 7,249
isolates were collected from clinical samples, among which 18.1% (1,311/7,249) were carbapenem resistant. Carbapenem-resistant
and carbapenem-resistant
were the two most common CRE species, with
carbapenemases (KPC) and New Delhi metallo-β-lactamases (NDM), respectively, responsible for the carbapenem resistance of the two species. Notably, >57.0% (
= 589) of the
isolates from the intensive care unit were carbapenem resistant. Furthermore,
and
were found to coexist in one
isolate, which exhibited resistance to almost all tested antibiotics. Overall, we observed a significant increase in the prevalence of CRE isolates during the study period and suggest that carbapenems may no longer be considered to be an effective treatment for infections caused by
in the studied hospital.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>29386265</pmid><doi>10.1128/JCM.01932-17</doi><orcidid>https://orcid.org/0000-0003-0866-4584</orcidid><oa>free_for_read</oa></addata></record> |
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| source | American Society for Microbiology; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Anti-Bacterial Agents - pharmacology beta-Lactamases - genetics Carbapenem-Resistant Enterobacteriaceae - drug effects Carbapenem-Resistant Enterobacteriaceae - genetics Carbapenems - pharmacology China - epidemiology Colistin - pharmacology Drug Resistance, Multiple, Bacterial - genetics Enterobacteriaceae Infections - epidemiology Epidemiology Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli Proteins - genetics Hospitals Humans Intensive Care Units Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Microbial Sensitivity Tests Prevalence |
| title | Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China |
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