Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms

Recent clinical trials of the hypoglycaemic sodium-glucose co-transporter-2 (SGLT2) inhibitors, which inhibit renal glucose reabsorption, have reported beneficial cardiovascular outcomes. Whether SGLT2 inhibitors directly affect cardiovascular tissues, however, remains unclear. We have previously re...

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Veröffentlicht in:	Scientific reports 2018-03, Vol.8 (1), p.5276-14, Article 5276
Hauptverfasser:	Mancini, Sarah J., Boyd, Daria, Katwan, Omar J., Strembitska, Anastasiya, Almabrouk, Tarek A., Kennedy, Simon, Palmer, Timothy M., Salt, Ian P.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/31 13/95 14 631/45 631/80/86 96 Adhesion AMP AMP-activated protein kinase AMP-Activated Protein Kinases - immunology Animals Anti-Inflammatory Agents - pharmacology c-Jun protein Canagliflozin - pharmacology Cell adhesion molecules Cell lines Cell surface Cells, Cultured Chemokines Chemokines - immunology Clinical trials Cytokines Cytokines - immunology Endothelial cells Endothelial Cells - drug effects Endothelial Cells - immunology Glucose transporter Hepatocytes Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans Inflammation Inhibitors Interleukin 6 Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - immunology JNK protein Kinases Mice Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes mRNA multidisciplinary Phosphorylation Proteins Reabsorption Science Science (multidisciplinary) Sodium Sodium-Glucose Transporter 2 Inhibitors - pharmacology Transcription factors
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