FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids

Epithelial progenitor cells are dependent upon a complex 3D niche to promote their proliferation and differentiation during development, which can be recapitulated in organoids. The specific requirements of the niche remain unclear for many cell types, including the proacinar cells that give rise to...

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Veröffentlicht in:	Journal of cell science 2018-02, Vol.131 (4), p.jcs208728-jcs208728
Hauptverfasser:	Hosseini, Zeinab F, Nelson, Deirdre A, Moskwa, Nicholas, Sfakis, Lauren M, Castracane, James, Larsen, Melinda
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - metabolism Animals Aquaporin 5 Aquaporin 5 - genetics Autocrine signalling Cell culture Cell Differentiation - genetics Cell proliferation Cell Proliferation - genetics Cells (biology) Clusters Conditioning Epidermal Growth Factor - genetics Epithelial cells Epithelial Cells - metabolism Fibroblast growth factor 2 Fibroblast Growth Factor 2 - genetics Gene Expression Regulation, Developmental Gene Knockdown Techniques Laminin Laminin - genetics Membrane proteins Mesenchyme Mesoderm - growth & development Mesoderm - metabolism Mice Morphogenesis NIH 3T3 Cells Organoids Organoids - growth & development Organoids - metabolism Primary Cell Culture Progenitor cells Proteins Saliva Saliva - metabolism Salivary gland Salivary Glands - growth & development Salivary Glands - metabolism Stem cells Stem Cells - metabolism Submandibular Gland - growth & development Submandibular Gland - metabolism
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