Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned

Although thiopurine S‐methyltransferase (TPMT) genotyping to guide thiopurine dosing is common in the pediatric cancer population, limited data exist on TPMT testing implementation in diverse, multidisciplinary settings. We established TPMT testing (genotype and enzyme) with clinical decision suppor...

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Veröffentlicht in:	Clinical and translational science 2018-03, Vol.11 (2), p.175-181
Hauptverfasser:	Weitzel, Kristin W., Smith, D. Max, Elsey, Amanda R., Duong, Benjamin Q., Burkley, Benjamin, Clare‐Salzler, Michael, Gong, Yan, Higgins, Tara A., Kong, Benjamin, Langaee, Taimour, McDonough, Caitrin W., Staley, Benjamin J., Vo, Teresa T., Wake, Dyson T., Cavallari, Larisa H., Johnson, Julie A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - standards Antimetabolites, Antineoplastic - therapeutic use Cancer therapies Child Child, Preschool Cytotoxicity Decision Support Systems, Clinical Dermatology Drug dosages Education Enzyme Assays - methods Enzymes Female Gastroenterology Genetic Testing - methods Genotype Genotype & phenotype Genotypes Genotyping Health care facilities Hematology Humans Inflammatory bowel disease Interdisciplinary Communication Intubation Male Metabolites Methyltransferase Methyltransferases - genetics Methyltransferases - metabolism Middle Aged Neoplasms - drug therapy Neoplasms - genetics Oncology Patient Education as Topic Patients Pediatrics Pharmacists Pharmacogenetics - methods Phenotype Polymorphism, Genetic Practice Guidelines as Topic Precision Medicine - methods Tertiary Care Centers
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