In vitro biotransformation of pyrrolizidine alkaloids in different species. Part I: Microsomal degradation

Pyrrolizidine alkaloids (PA) are secondary metabolites of certain flowering plants. The ingestion of PAs may result in acute and chronic effects in man and livestock with hepatotoxicity, mutagenicity, and carcinogenicity being identified as predominant effects. Several hundred PAs sharing the diol p...

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Veröffentlicht in:	Archives of toxicology 2018-03, Vol.92 (3), p.1089-1097
Hauptverfasser:	Kolrep, Franziska, Numata, Jorge, Kneuer, Carsten, Preiss-Weigert, Angelika, Lahrssen-Wiederholt, Monika, Schrenk, Dieter, These, Anja
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Biocompatibility Biomedical and Life Sciences Biomedicine Biotransformation Carcinogenicity Carcinogens Chronic effects Congeners Degradation Environmental Health Flowering Hepatotoxicity Horses Ingestion Liver Livestock Metabolic activation Metabolic rate Metabolism Metabolites Mutagenicity Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Plants (organisms) Pyrrolizidine alkaloids Secondary metabolites Sheep Species Toxicity Toxicokinetics and Metabolism Toxicology
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