Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition

Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal obliteration is a major contributor to the elevated pulmonary vascular resistance in patients with idiopathic pulmonary arterial hypertension (IPAH). Here we report that increased hypoxia-inducible factor 2α (...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2018-02, Vol.314 (2), p.L256-L275
Hauptverfasser:	Tang, Haiyang, Babicheva, Aleksandra, McDermott, Kimberly M, Gu, Yali, Ayon, Ramon J, Song, Shanshan, Wang, Ziyi, Gupta, Akash, Zhou, Tong, Sun, Xutong, Dash, Swetaleena, Wang, Zilu, Balistrieri, Angela, Zheng, Qiuyu, Cordery, Arlette G, Desai, Ankit A, Rischard, Franz, Khalpey, Zain, Wang, Jian, Black, Stephen M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - physiology Cells, Cultured Endothelial Cells - metabolism Endothelial Cells - pathology Epithelial-Mesenchymal Transition Hypertension, Pulmonary - etiology Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypoxia - physiopathology Hypoxia-Inducible Factor 1, alpha Subunit - physiology Hypoxia-Inducible Factor-Proline Dioxygenases - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Vascular Remodeling
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