TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells

Hyperglycemia-induced production of endothelin (ET)-1 is a hallmark of endothelial dysfunction in diabetes. Although the detrimental vascular effects of increased ET-1 are well known, the molecular mechanisms regulating endothelial synthesis of ET-1 in the setting of diabetes remain largely unidenti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2018-01, Vol.314 (1), p.H52-H64
Hauptverfasser:	Padilla, Jaume, Carpenter, Andrea J, Das, Nitin A, Kandikattu, Hemanth Kumar, López-Ongil, Susana, Martinez-Lemus, Luis A, Siebenlist, Ulrich, DeMarco, Vincent G, Chandrasekar, Bysani
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adapters Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adhesion Animals Aorta Cell Adhesion Cell Adhesion Molecules - metabolism Cells, Cultured Chemical synthesis Coculture Techniques Complications Cytokines - metabolism Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetic Angiopathies - chemically induced Diabetic Angiopathies - genetics Diabetic Angiopathies - metabolism E-selectin Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelin 1 Endothelin-1 - genetics Endothelin-1 - metabolism Endothelin-1 - toxicity Endothelium Female Glucose Glucose - toxicity Humans Hyperglycemia I-kappa B Kinase - metabolism IL-1β Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation Mediators - metabolism Inhibition Intercellular adhesion molecule 1 JNK protein Male Mice, Inbred NOD Mitogen-Activated Protein Kinase 8 - metabolism Molecular modelling Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes - metabolism NAD(P)H oxidase Pharmacology Proteins Reactive oxygen species Signal Transduction - drug effects Transcription Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism Tumor necrosis factor-α Vascular cell adhesion molecule 1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!