Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR

Perinatal exposures are associated with altered risks of childhood allergy. Human studies and our previous work suggest that restricted growth in utero (IUGR) is protective against allergic disease. The mechanisms are not clearly defined, but reduced fetal abundance and altered metabolism of methyl...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2018-01, Vol.314 (1), p.R22-R33
Hauptverfasser:	Wooldridge, Amy L, Bischof, Robert J, Liu, Hong, Heinemann, Gary K, Hunter, Damien S, Giles, Lynne C, Simmons, Rebecca A, Lien, Yu-Chin, Lu, Wenyun, Rabinowitz, Joshua D, Kind, Karen L, Owens, Julie A, Clifton, Vicki L, Gatford, Kathryn L
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Animals Antibodies Cell density Children Cobalt - administration & dosage Dermatitis - immunology Dermatitis - prevention & control Diet Dietary Supplements Disease Models, Animal DNA Methylation Feed additives Female Fetal Growth Retardation - immunology Fetuses Folic Acid - administration & dosage Gestation Gestational Age House dust Hypersensitivity Hypersensitivity - immunology Hypersensitivity - prevention & control Immune system Immunoglobulin E - immunology Intervention Mast Cells - immunology Metabolism Methionine - administration & dosage Offspring Ovalbumin Ovalbumin - immunology Ovis aries Placenta - immunology Pregnancy Prenatal Exposure Delayed Effects Progeny Pyroglyphidae - immunology Sheep Sheep, Domestic Skin Skin - immunology Sulfur - administration & dosage
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