Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity

Methylation at the 5 position of cytosine in DNA (5meC) is a key epigenetic mark in eukaryotes. Once introduced, 5meC can be maintained through DNA replication by the activity of ‘maintenance’ DNA methyltransferases (DNMTs). Despite their ancient origin, DNA methylation pathways differ widely across...

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Veröffentlicht in:	Nature genetics 2018-03, Vol.50 (3), p.452-459
Hauptverfasser:	Rošić, Silvana, Amouroux, Rachel, Requena, Cristina E., Gomes, Ana, Emperle, Max, Beltran, Toni, Rane, Jayant K., Linnett, Sarah, Selkirk, Murray E., Schiffer, Philipp H., Bancroft, Allison J., Grencis, Richard K., Jeltsch, Albert, Hajkova, Petra, Sarkies, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 45/22 45/23 631/114/2785 631/208 631/208/212 631/337/176 82/58 Agriculture Alkylation Animal Genetics and Genomics Animals Biocompatibility Biological evolution Biomedical and Life Sciences Biomedicine Caenorhabditis elegans Cancer Research Cell division Conserved Sequence Crustaceans Cytosine Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferases - metabolism DNA biosynthesis DNA Damage DNA methylation DNA Methylation - physiology DNA methyltransferase DNA repair DNA replication DNA Transposable Elements - physiology Enzymes Epigenetic inheritance Epigenetics Eukaryota - classification Eukaryota - genetics Eukaryotes Evolution Evolution, Molecular Gene Function Genes Genetic aspects Genetic regulation Genomes Human Genetics Humans Mermithoidea Methylation Methyltransferases Mice Mice, SCID Nematoda - classification Nematoda - genetics Nematodes Phylogeny Pyrimidines Roundworms Sequence Alignment Sequence Analysis, Protein Stem cells Transferases Trichuris
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