Gender-Specific Expression of ATP-binding Cassette ( Abc ) Transporters and Cytoprotective Genes in Mouse Choroid Plexus

Abstract The choroid plexus (CP) and blood-brain barrier (BBB) control the movement of several drugs and endogenous compounds between the brain and systemic circulation. The multidrug resistance associated protein (Mrp) efflux transporters form part of these barriers. Several Mrp transporters are po...

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Veröffentlicht in:	Toxicology (Amsterdam) 2017-07, Vol.386, p.84-92
Hauptverfasser:	Flores, Katiria, Manautou, José E, Renfro, J. Larry
Format:	Artikel
Sprache:	eng
Schlagworte:	Abc transporters Animals ATP-Binding Cassette Transporters - genetics blood-brain barrier Blood-Brain Barrier - metabolism brain cAMP Choroid plexus Choroid Plexus - metabolism Cytoprotective genes Emergency epithelium Female females Gender gender differences Gene Expression Regulation genes Kidney - metabolism kidneys liver Liver - metabolism Male males methotrexate Methotrexate - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Mrp4 Multidrug Resistance-Associated Proteins - genetics multiple drug resistance NF-E2-Related Factor 2 - metabolism Probenecid - pharmacology quantitative polymerase chain reaction Sex Factors transcription factors transporters
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