The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial

IgA secretion at mucosal sites is important for host defence against pathogens as well as maintaining the symbiosis with microorganisms present in the small intestine that affect IgA production. In the present study, we tested the ability of 5 strains of lactic acid bacteria stimulating IgA producti...

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Veröffentlicht in:	Scientific reports 2018-03, Vol.8 (1), p.5065-9, Article 5065
Hauptverfasser:	Kawashima, Tadaomi, Ikari, Naho, Kouchi, Tomoko, Kowatari, Yasuyuki, Kubota, Yoshiro, Shimojo, Naoki, Tsuji, Noriko M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/21 631/250/2152/2153 631/326/107 692/308/2779/777 Adult Animals Bacteria Clinical trials Dendritic cells Dendritic Cells - metabolism Dendritic Cells - microbiology Double-stranded RNA Female Gastric Mucosa - metabolism Gastric Mucosa - microbiology Humanities and Social Sciences Humans Immunoglobulin A Immunoglobulin A, Secretory - biosynthesis Immunoglobulin A, Secretory - metabolism Ingestion Interleukin 10 Interleukin 6 Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-6 - biosynthesis Interleukin-6 - genetics Intestine, Small - metabolism Intestine, Small - microbiology Lactic acid Lactic acid bacteria Lactobacillales - immunology Lactobacillales - metabolism Male Microorganisms Middle Aged Mucosa multidisciplinary Pediococcus acidilactici Pediococcus acidilactici - immunology Pediococcus acidilactici - metabolism RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism Saliva Saliva - metabolism Saliva - microbiology Science Science (multidisciplinary) Small intestine Symbiosis
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