A new diagnostic test for Creutzfeldt-Jakob disease: Real-time quaking-induced conversion (RT-QulC)

A new diagnostic test for Creutzfeldt-Jakob disease: Real-time quaking-induced conversion (RT-QulC)

Currently, definitive diagnoses of Creutzfeldt-Jakob disease (CJD) require an examination of the brains of deceased patients. In cooperation with an international consortium, Canada's National Microbiology Laboratory is performing a validation of a new test that can diagnose CJD in living patie...

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Veröffentlicht in:Canada communicable disease report 2015-08, Vol.41 (8), p.192-195
Hauptverfasser: Godal, D, Simon, Slr, Cheng, K, Knox, J D
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Bovine spongiform encephalopathy
Brain
Consortia
Creutzfeldt-Jakob disease
Innovation
Laboratories
NMR
Nuclear magnetic resonance
Patients
Proteins
Public health
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container_title Canada communicable disease report
container_volume 41
creator Godal, D
Simon, Slr
Cheng, K
Knox, J D
description Currently, definitive diagnoses of Creutzfeldt-Jakob disease (CJD) require an examination of the brains of deceased patients. In cooperation with an international consortium, Canada's National Microbiology Laboratory is performing a validation of a new test that can diagnose CJD in living patients. This test, the real-time quaking-induced conversion (RT-QuIC) assay, directly detects the disease associated form of the prion protein in cerebrospinal fluid. If validated, RT-QuIC will represent a major advance in the diagnoses of patients suspected to have CJD.
doi_str_mv 10.14745/ccdr.v41i08a02
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source PubMed Central; Alma/SFX Local Collection; EZB Electronic Journals Library
subjects Alzheimer's disease
Bovine spongiform encephalopathy
Brain
Consortia
Creutzfeldt-Jakob disease
Innovation
Laboratories
NMR
Nuclear magnetic resonance
Patients
Proteins
Public health
title A new diagnostic test for Creutzfeldt-Jakob disease: Real-time quaking-induced conversion (RT-QulC)
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