Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins

The prosurvival Bcl-2 family proteins Mcl-1 and Bcl-x L inhibit apoptosis by sequestering BH3-only proteins such as Bid and Bim (MODE 1) or the effector proteins Bak and Bax (MODE 2). To better understand the contributions of MODE 1 and MODE 2 in blocking cell death, and thus how to bypass resistanc...

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Veröffentlicht in:	Cell death and differentiation 2018-03, Vol.25 (4), p.721-734
Hauptverfasser:	Hockings, Colin, Alsop, Amber E., Fennell, Stephanie C., Lee, Erinna F., Fairlie, W. Douglas, Dewson, Grant, Kluck, Ruth M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1244 631/80 Apoptosis Bax protein Bcl-2 protein Bcl-x protein BIM protein Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Cycle Analysis Cell death Life Sciences Mcl-1 protein Proteins Stem Cells
Online-Zugang:	Volltext
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