CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells

The CDK8/19 kinase module comprises a subcomplex that interacts with the Mediator complex and regulates gene expression through phosphorylation of transcription factors and Mediator subunits. Mediator complex subunits have been increasingly implicated in cancer and other diseases. Although high expr...

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Veröffentlicht in:	Oncotarget 2018-03, Vol.9 (17), p.13474-13487
Hauptverfasser:	Nakamura, Akito, Nakata, Daisuke, Kakoi, Yuichi, Kunitomo, Mihoko, Murai, Saomi, Ebara, Shunsuke, Hata, Akito, Hara, Takahito
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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