Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma

In esophageal squamous cell carcinoma (ESCC), a subset of cells defined by high expression of CD44 and low expression of CD24 has been reported to possess characteristics of cancer stem-like cells (CSCs). Novel therapies directly targeting CSCs have the potential to improve prognosis of ESCC patient...

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Veröffentlicht in:	Carcinogenesis (New York) 2017-10, Vol.38 (11), p.1073-1083
Hauptverfasser:	Maehara, Osamu, Suda, Goki, Natsuizaka, Mitsuteru, Ohnishi, Shunsuke, Komatsu, Yoshito, Sato, Fumiyuki, Nakai, Masato, Sho, Takuya, Morikawa, Kenichi, Ogawa, Koji, Shimazaki, Tomoe, Kimura, Megumi, Asano, Ayaka, Fujimoto, Yoshiyuki, Ohashi, Shinya, Kagawa, Shingo, Kinugasa, Hideaki, Naganuma, Seiji, Whelan, Kelly A, Nakagawa, Hiroshi, Nakagawa, Koji, Takeda, Hiroshi, Sakamoto, Naoya
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides - pharmacology Biology, Genetics and Epigenetics Carcinoma, Squamous Cell - metabolism Cell Line, Tumor Editor's Choice Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology Esophageal Neoplasms - metabolism Esophageal Squamous Cell Carcinoma Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblast Growth Factor 2 - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - physiology Humans MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Piperazines - pharmacology Pyrazoles - pharmacology Pyridones - pharmacology Pyrimidinones - pharmacology Receptors, Fibroblast Growth Factor - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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