Functional Characterization of Three Specific Acyl-Coenzyme A Synthetases Involved in Anaerobic Cholesterol Degradation in Sterolibacterium denitrificans Chol1S

The denitrifying betaproteobacterium Chol1S catabolizes steroids such as cholesterol via an oxygen-independent pathway. It involves enzyme reaction sequences described for aerobic cholesterol and bile acid degradation as well as enzymes uniquely found in anaerobic steroid-degrading bacteria. Recent...

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Veröffentlicht in:	Applied and environmental microbiology 2018-04, Vol.84 (7), p.e02721-17
Hauptverfasser:	Warnke, Markus, Jung, Tobias, Jacoby, Christian, Agne, Michael, Feller, Franziska Maria, Philipp, Bodo, Seiche, Wolfgang, Breit, Bernhard, Boll, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids AMP Anaerobiosis Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biodegradation Chains Chemical reactions Cholesterol Cholesterol - metabolism Coenzyme A Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Degradation Enzyme kinetics Forming Hip Hydroxylation Oxidation Oxygen Rhodocyclaceae - genetics Rhodocyclaceae - physiology Steroid hormones Steroids Substrates
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