Suppressor of cytokine signalling-2 limits IGF1R-mediated regulation of epithelial–mesenchymal transition in lung adenocarcinoma

Non-small cell lung cancer (NSCLC), including adenocarcinoma and squamous cell carcinoma, is the leading cause of death from lung malignancies and has a poor prognosis due to metastasis. Suppressor of cytokine signalling-2 (SOCS2), a feedback inhibitor of cytokine signalling, has been shown to be in...

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Veröffentlicht in:	Cell death & disease 2018-03, Vol.9 (4), p.429-14, Article 429
Hauptverfasser:	Zhou, Yue, Zhang, Zhilei, Wang, Ning, Chen, Jizheng, Zhang, Xu, Guo, Min, John Zhong, Li, Wang, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/2 13/31 13/51 13/89 13/95 14/19 38/22 38/77 45/90 64/60 82/80 Adenocarcinoma Aged Animals Antibodies Biochemistry Biomedical and Life Sciences Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cell Biology Cell Culture Cell Line, Tumor Cell Movement Cytokines Epithelial-Mesenchymal Transition Female Gene expression Humans Immunology Insulin Insulin-like growth factor I Invasiveness Kaplan-Meier Estimate Life Sciences Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Lungs Lymph nodes Lymphatic system Male Medical prognosis Mesenchyme Metastases Metastasis Mice Mice, Nude Middle Aged Non-small cell lung carcinoma Pathogenicity Protein Binding Receptor, IGF Type 1 - metabolism Signal Transduction Squamous cell carcinoma Stat3 protein STAT3 Transcription Factor - metabolism Stat5 protein STAT5 Transcription Factor - metabolism Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - metabolism Transcription Tumors
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