Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta
Foldit Standalone is an interactive graphical interface to the Rosetta molecular modeling package. In contrast to most command-line or batch interactions with Rosetta, Foldit Standalone is designed to allow easy, real-time, direct manipulation of protein structures, while also giving access to the e...
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| Veröffentlicht in: | Bioinformatics (Oxford, England) England), 2017-09, Vol.33 (17), p.2765-2767 |
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| container_title | Bioinformatics (Oxford, England) |
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| creator | Kleffner, Robert Flatten, Jeff Leaver-Fay, Andrew Baker, David Siegel, Justin B Khatib, Firas Cooper, Seth |
| description | Foldit Standalone is an interactive graphical interface to the Rosetta molecular modeling package. In contrast to most command-line or batch interactions with Rosetta, Foldit Standalone is designed to allow easy, real-time, direct manipulation of protein structures, while also giving access to the extensive power of Rosetta computations. Derived from the user interface of the scientific discovery game Foldit (itself based on Rosetta), Foldit Standalone has added more advanced features and removed the competitive game elements. Foldit Standalone was built from the ground up with a custom rendering and event engine, configurable visualizations and interactions driven by Rosetta. Foldit Standalone contains, among other features: electron density and contact map visualizations, multiple sequence alignment tools for template-based modeling, rigid body transformation controls, RosettaScripts support and an embedded Lua interpreter.
Foldit Standalone is available for download at https://fold.it/standalone , under the Rosetta license, which is free for academic and non-profit users. It is implemented in cross-platform C ++ and binary executables are available for Windows, macOS and Linux.
scooper@ccs.neu.edu. |
| doi_str_mv | 10.1093/bioinformatics/btx283 |
| format | Article |
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Foldit Standalone is available for download at https://fold.it/standalone , under the Rosetta license, which is free for academic and non-profit users. It is implemented in cross-platform C ++ and binary executables are available for Windows, macOS and Linux.
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Foldit Standalone is available for download at https://fold.it/standalone , under the Rosetta license, which is free for academic and non-profit users. It is implemented in cross-platform C ++ and binary executables are available for Windows, macOS and Linux.
scooper@ccs.neu.edu.</description><subject>Applications Notes</subject><subject>bioinformatics</subject><subject>Computational Biology - methods</subject><subject>computer software</subject><subject>Models, Molecular</subject><subject>molecular models</subject><subject>Protein Conformation</subject><subject>protein structure</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, Protein - methods</subject><subject>Software</subject><subject>user interface</subject><subject>Video Games</subject><issn>1367-4803</issn><issn>1460-2059</issn><issn>1367-4811</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAUhUVJaB7tT2jRMhsnkmXZcheFEpoHBApJ1hHX1tVExZamkjyk_z4qkwzJqqsruN85ks4h5Atnp5z14mxwwXkb4gzZjelsyE-1Eh_IIRdtVzWK873dmYkDcpTSb8aYZLL9SA5qVYi-Y4fk4SJMxmV6l8EbmILHbxToxhkMdAUzVgaj26Ch6xgyOk9TjsuYl4h0Bu_Wy1TuD546nzFaGJEuyfkVvQ0Jc4ZPZN_ClPDzyzwm9xc_78-vqptfl9fnP26qUXKWKz40IGxjpGTWCOyEsJ0ZDUqlLGdC2hoBBssG3hgLUnW270oKqrGy74r0mHzf2q6XYUYzos8RJr2Obob4Vwdw-v3Gu0e9ChstVctYK4rByYtBDH8WTFnPLo04TeAxLEnXtRR1gUuW_0O56lvV85rJgsotOsaQUkS7exFn-l-L-n2Letti0X19-52d6rU28QzT3aG1</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Kleffner, Robert</creator><creator>Flatten, Jeff</creator><creator>Leaver-Fay, Andrew</creator><creator>Baker, David</creator><creator>Siegel, Justin B</creator><creator>Khatib, Firas</creator><creator>Cooper, Seth</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta</title><author>Kleffner, Robert ; Flatten, Jeff ; Leaver-Fay, Andrew ; Baker, David ; Siegel, Justin B ; Khatib, Firas ; Cooper, Seth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-1b4a3f4d550fd3e733f7dcde588f1035f2eaabf0b14dfa587f9710984f5974a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Applications Notes</topic><topic>bioinformatics</topic><topic>Computational Biology - methods</topic><topic>computer software</topic><topic>Models, Molecular</topic><topic>molecular models</topic><topic>Protein Conformation</topic><topic>protein structure</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, Protein - methods</topic><topic>Software</topic><topic>user interface</topic><topic>Video Games</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kleffner, Robert</creatorcontrib><creatorcontrib>Flatten, Jeff</creatorcontrib><creatorcontrib>Leaver-Fay, Andrew</creatorcontrib><creatorcontrib>Baker, David</creatorcontrib><creatorcontrib>Siegel, Justin B</creatorcontrib><creatorcontrib>Khatib, Firas</creatorcontrib><creatorcontrib>Cooper, Seth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioinformatics (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kleffner, Robert</au><au>Flatten, Jeff</au><au>Leaver-Fay, Andrew</au><au>Baker, David</au><au>Siegel, Justin B</au><au>Khatib, Firas</au><au>Cooper, Seth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta</atitle><jtitle>Bioinformatics (Oxford, England)</jtitle><addtitle>Bioinformatics</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>33</volume><issue>17</issue><spage>2765</spage><epage>2767</epage><pages>2765-2767</pages><issn>1367-4803</issn><issn>1460-2059</issn><eissn>1367-4811</eissn><abstract>Foldit Standalone is an interactive graphical interface to the Rosetta molecular modeling package. In contrast to most command-line or batch interactions with Rosetta, Foldit Standalone is designed to allow easy, real-time, direct manipulation of protein structures, while also giving access to the extensive power of Rosetta computations. Derived from the user interface of the scientific discovery game Foldit (itself based on Rosetta), Foldit Standalone has added more advanced features and removed the competitive game elements. Foldit Standalone was built from the ground up with a custom rendering and event engine, configurable visualizations and interactions driven by Rosetta. Foldit Standalone contains, among other features: electron density and contact map visualizations, multiple sequence alignment tools for template-based modeling, rigid body transformation controls, RosettaScripts support and an embedded Lua interpreter.
Foldit Standalone is available for download at https://fold.it/standalone , under the Rosetta license, which is free for academic and non-profit users. It is implemented in cross-platform C ++ and binary executables are available for Windows, macOS and Linux.
scooper@ccs.neu.edu.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28481970</pmid><doi>10.1093/bioinformatics/btx283</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Open Access Collection; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Applications Notes bioinformatics Computational Biology - methods computer software Models, Molecular molecular models Protein Conformation protein structure Sequence Alignment Sequence Analysis, Protein - methods Software user interface Video Games |
| title | Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta |
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