Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells

Mutations in the human dynamin-related protein Drp1 cause mitochondria to form perinuclear clusters. We show here that these mitochondrial clusters consist of highly interconnected mitochondrial tubules. The increased connectivity between mitochondria indicates that the balance between mitochondrial...

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Veröffentlicht in:	Molecular biology of the cell 2001-08, Vol.12 (8), p.2245-2256
Hauptverfasser:	Smirnova, E, Griparic, L, Shurland, D L, van der Bliek, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Fractionation Cell Line COS Cells Cytosol - metabolism Genes, Reporter GTP Phosphohydrolases Humans Immunoblotting Microscopy, Fluorescence Microtubule-Associated Proteins Mitochondria - metabolism Mitochondria - physiology Mitochondria - ultrastructure Mitochondrial Proteins Mutation Phenotype Proteins - chemistry Proteins - genetics Proteins - isolation & purification Proteins - metabolism Recombinant Fusion Proteins - metabolism Temperature Transfection
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