Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury

The complement system is implicated in promoting acute secondary injury after traumatic brain injury (TBI), but its role in chronic post-traumatic neuropathology remains unclear. Using various injury-site targeted complement inhibitors that block different complement pathways and activation products...

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Veröffentlicht in:	The Journal of neuroscience 2018-03, Vol.38 (10), p.2519-2532
Hauptverfasser:	Alawieh, Ali, Langley, E Farris, Weber, Shannon, Adkins, DeAnna, Tomlinson, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative pathway Brain CD59 antigen Clinical trials Cognitive ability Complement Complement activation Complement component C3 Complement inhibitors Cortex Crry protein Dendrites Head injuries Immunogenicity Inflammation Inhibition Medical research Membrane attack complex Neurodegeneration Neuropathology Recovery of function Synapses Synaptic density Therapeutic applications Traumatic brain injury Upstream
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